Chronic stress fuels cancer by releasing stress mediators that remodel the tumor and stromal cells, promoting immune evasion, angiogenesis, and metastasis. A review in Science Bulletin underscores how blocking this signaling could improve outcomes and proposes stress management as a potential component of precision oncology.

A multicenter study led by Prof. Shuixing Zhang and Prof. Bin Zhang from the First Affiliated Hospital of Jinan University enrolled 246 patients with locally advanced NPC treated with immunotherapy. By applying artificial intelligence algorithms, the team extracted and selected optimal radiomic features from medical imaging to construct a predictive model.

The University of Osaka scientists have developed a safe, efficient “dump-and-stir” method to introduce ortho-carborane into various aromatic compounds using a newly designed lithium–copper reagent. This innovation overcomes the complexity and hazards of previous methods, paving the way for new applications in boron neutron capture therapy (BNCT), three-dimensional aromatic materials, and bioisosteric drug design.