COVID-19 leaves a lasting mark on the human brain
Peer-Reviewed Publication
Updates every hour. Last Updated: 15-Dec-2025 20:11 ET (16-Dec-2025 01:11 GMT/UTC)
COVID-19 does not just affect the respiratory system, but also significantly alters the brain in people who have fully recovered from the infectious disease, highlighting the long-term neurological impact of the virus.
Australian scientists have identified the key genetic drivers behind long COVID, revealing why some people continue to experience debilitating symptoms long after their initial infection.
Pregnant people who received a COVID-19 vaccine were far less likely to experience severe illness or deliver their babies prematurely, according to a major new UBC-led study published in JAMA. Drawing on data from nearly 20,000 pregnancies across Canada, the research found that vaccination was strongly associated with lower risks of hospitalization, intensive care admission and preterm birth. These benefits persisted as the virus evolved from the Delta variant to Omicron, which has evolved into newer sublineages that still dominate today.
A University of Maryland, Baltimore County (UMBC) study, published in Nature Communications, uncovers how enteroviruses—including those causing polio, myocarditis, encephalitis, and the common cold—hijack host cell machinery to replicate. Researchers determined the structure of a cloverleaf-shaped RNA element in the viral genome bound to the viral protein 3CD, which recruits host factors to form the viral replication complex. 3CD also acts as a switch between genome copying and protein synthesis. This highly conserved mechanism across all seven enteroviruses in the study presents a stable target for developing broad-spectrum antiviral drugs that could disrupt this essential interaction and prevent replication.
Simulations of Turin, Milan and Palermo reveal that individual behaviour affects the intensity and timing of epidemics spreading in urban areas.