Figure 3. Induction of depression-like behaviors by reduced St3gal1 expression in the mPFC (IMAGE)

Institute for Basic Science

Figure 3. Induction of depression-like behaviors by reduced St3gal1 expression in the mPFC

Caption

Injection of a virus suppressing St3gal1 expression (shSt3gal1) into the prefrontal cortex of normal mice induced depression-like behaviors. These mice exhibited increased latency to feed in a novel environment, reflecting heightened anxiety and reduced feeding motivation (NSFT, novelty-suppressed feeding test), as well as decreased sucrose preference, indicating anhedonia (SPT, sucrose preference test).

Credit

Institute for Basic Science

Usage Restrictions

Attribution Required

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.