Figure 2. Altered brain O-glycosylation in control and stressed mice (IMAGE)
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O-glycan expression patterns were compared across nine brain regions in control (CON) and chronic variable stress (CVS) mice (left). Region-specific glycosylation profiles were observed throughout the brain, with stress-induced changes most pronounced in the prefrontal cortex (PFC), cerebellar cortex (CC), olfactory bulb (OLB), and diencephalon (DIE) (right). These findings indicate that chronic stress disrupts O-glycosylation, particularly O-glycan sialylation, in specific brain regions, potentially contributing to depression-like behaviors.
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