KAIST Develops Core Technology to Reverse Biological Changes Once Thought Irreversible, Opening New Possibilities for Aging and Cancer Research (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

KAIST Develops Core Technology to Reverse Biological Changes Once Thought Irreversible, Opening New Possibilities for Aging and Cancer Research

Caption

[Figure 4] Analysis and control of irreversibility in intestinal epithelial cell differentiation based on single-cell data

The team constructed a logic-based regulatory network from single-cell transcriptome data of human intestinal epithelial cells and applied ROOT to identify the irreversibility kernel and its key regulator, SMAD3. Based on this, the team showed that inhibiting SMAD3 is the optimal resetting-control strategy for restoring cells to their pre-differentiation state.

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KAIST

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