KAIST Develops Core Technology to Reverse Biological Changes Once Thought Irreversible, Opening New Possibilities for Aging and Cancer Research (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

KAIST Develops Core Technology to Reverse Biological Changes Once Thought Irreversible, Opening New Possibilities for Aging and Cancer Research

Caption

[Figure 3] Analysis of irreversibility in hematopoietic stem cell differentiation using ROOT

In oxygen-induced irreversible differentiation of hematopoietic stem cells, the team identified the irreversibility kernel as the AKT–p53–FOXO3 positive feedback loop together with a Meis1 self-loop that satisfies ROOT's defining condition for the repression of Runx1 and PU.1. Based on this, the team derived an optimal resetting-control strategy capable of restoring cells to their initial, undifferentiated state.

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KAIST

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