Fig.3. (IMAGE) Osaka University Caption Screening of metastatic carcinoma nodules in lymph nodes with CUBIC. (Upper) Schematic diagram of the metastasis screening protocol. (Middle) The representative images of reconstructed 3-D model, H&E staining, or Cytokeratin immunohistochemical (IHC) staining of the lymph node contained small carcinoma nodules which were only identified by CUBIC screening but were not detected by routine diagnosis method. (Lower) The results of screening are summarized in the table. Four lymph nodes out of 74 were newly diagnosed as positive for metastasis only by the CUBIC-based screening, making the sensitivity of the conventional diagnosis method 85.2 percent (23/27) with four false negative, i.e. 14.8 percent (4/27) improvement in sensitivity with CUBIC. Credit 2017 Nojima S. et al. <i>Scientific Reports</i>, 7:9269, 1-14. DOI: 10.1038/s41598-017-09117-0 Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.