Alveolar bone defects can cause periodontal dehiscence, leading to exposure of dental roots, recession of gums, and increased tooth sensitivity. In a new study, researchers have evaluated the therapeutic potential of abaloparatide (ABL), a synthetic analog of human parathyroid hormone-related protein(PTHrP), in alleviating periodontal dehiscence. Utilizing rat models undergoing orthodontic tooth movement, they demonstrate that submucosal injection of ABL induces alveolar bone formation through a focal adhesion kinase(FAK)-driven mechanism.

A collaborative research team from Peking University has developed a novel method to enhance the tumor-targeting efficiency of γδ T cells through chemical engineering. By conjugating or gluing the cancer cell-targeting antibodies to γδ T cells via fast metabolic glycan labeling and click chemistry, the team achieved improved anti-tumor efficacy both in vitro and in vivo. This innovative approach holds significant promise for advancing adoptive cell therapy in cancer treatment.

A research paper just published in Science China Life Sciences reports that the rice ribosome-associated quality control 1 (OsRqc1) regulates the temperature threshold in thermo-sensitive genic male sterility 5 (tms5) lines by assisting OsVms1 in recruiting 60S ribosomal subunits to generate cP-ΔCCA-tRNAs, with its allelic variations offering a novel tool for two-line hybrid breeding of japonica rice tms5 lines.

Research teams from Tsinghua University and Anhui University of Technology have developed a novel post-processing technique using hot isostatic pressing (HIP) to improve the microstructure and wear resistance of titanium alloy surfaces. Through a careful combination of temperature and pressure, the team achieved remarkable reductions in residual stress-up to eightfold-and enhanced mechanical properties, including increased hardness and ductility. This fabrication process promotes better phase stability and interfacial bonding, enabling the coated titanium components to withstand extreme temperatures and harsh environments more effectively. This technology effectively overcomes the long-standing challenge of poor wear resistance in titanium alloys, offering a solid theoretical foundation and valuable technical guidance for the laser in-situ fabrication of TiN/Ti composite surface modification layers. The outcomes of this work hold significant potential to transform industries such as aerospace, biomedical implants, and industrial tooling—paving the way for more durable, reliable, and high-performance titanium-based components.

A recent study published in National Science Review introduces an integrated ecological–social framework linking urban environments with subjective well-being (SWB) across 107 Chinese cities. Using millions of street view images and social media posts, the study shows urbanization reduces SWB disparities, with ecological factors boosting SWB among lower well-being groups and social–economic factors benefiting higher groups, highlighting pathways to healthier, more equitable cities.

Neoadjuvant therapies, or treatments given before surgery, are changing how doctors treat locally advanced colon cancer. In a recent review, researchers from the United States examined how pre-surgical chemotherapy and immunotherapy can shrink tumors, reduce recurrence, and improve surgical outcomes. They discussed clinical trials like FOxTROT and NICHE and highlighted the importance of using mismatch repair (MMR) status to guide treatment decisions and improve patient outcomes through personalized care strategies.