Decoding sepsis: Unraveling key signaling pathways for targeted therapies
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Dec-2025 15:12 ET (23-Dec-2025 20:12 GMT/UTC)
The research conducted by Professor Zou Zui and his team focuses on the immunoregulatory mechanisms in sepsis. As a life-threatening systemic inflammatory response syndrome triggered by infection, sepsis often leads to multiple organ failure, with the NF-κB signaling pathway playing a pivotal role in this pathophysiological process.
Recently, the team of Shao Jiangjuan/Zheng Shizhong/Cheng Haibo from Nanjing University of Chinese Medicine revealed a dual regulatory mechanism: inhibition of SIRT7 by Oroxylin A (OA) reprograms the fate of HSCs through PRMT5 succinylation-driven senescence and ecto-calreticulin (ecto-CRT)-dependent NK cell immune clearance. The study achieved a significant reduction in fibrosis markers in experimental models and highlighted the critical role of inhibiting the SIRT7 protein.
A review paper by scientists at the Harbin Institute of Technology proposed the signal-enhancing mechanisms of MNMs in single-modal imaging and explored multimodal applications through MNMs-probe design and discusses artificial intelligence-driven intelligent MNMs for precision imaging.
The new research paper, published on Sep. 10 in the journal Cyborg and Bionic Systems, presented recent advancements in their applications for multimodal imaging and integration with artificial intelligence (AI)-driven technologies.