A research paper by scientists at The Second Affiliated Hospital of Zhejiang University School of Medicine presented the application of Ultrasound Localization Microscopy (ULM) for monitoring the progression of Type 2 Diabetes and assessing the efficacy of anti-cytokine immunotherapy.

Malaria, an infectious disease caused by Plasmodium parasites, is pathologically linked to the dynamic equilibrium of host innate immune responses. Neutrophils, as pivotal effector cells of the innate immune system, constitute the first line of defense against pathogen invasion. Previous work by Professor Qijun Chen's team demonstrated that neutrophils significantly suppress Plasmodium proliferation during early infection through the release of neutrophil extracellular traps (NETs). However, the precise functional specialization and regulatory dynamics of neutrophil subsets during malaria infection have yet to be fully elucidated. Building upon these findings, the team's preliminary investigations revealed that oral gavage administration of dihydroartemisinin (DHA)—a widely deployed antimalarial drug—in murine models induced a marked elevation in the proportion of splenic Ly6G⁺ neutrophils. Nevertheless, the mechanistic basis underlying the antimalarial efficacy of this specific neutrophil subpopulation, particularly its immunomodulatory capacity, remains deep exploration.

A comprehensive review titled “From the Test Tube to the Cell: A Homecoming for DNA Computing Circuits?" published Mar. 4 in Intelligent Computing, a Science Partner Journal, highlights progress in operating DNA computing circuits for operation within living cells. According to the authors, dynamic nanodevices powered by DNA strand displacement reactions could soon enable real-time computing, sensing and actuation inside biological systems—and usher in a new era of “molecular robots” that interact with cellular environments.

Recently, the research teams led by Professors Yu Tao and Feng Yugong from The Affiliated Hospital of Qingdao University collaborated to investigate the functional roles and underlying mechanisms of a novel class of small non-coding RNAs—tsRNAs—in the pathogenesis of intracranial aneurysms. Their findings were published in Research under the title, "tRF-AspGTC Promotes Intracranial Aneurysm Formation by Regulating TRIM29-Mediated Galectin-3 Ubiquitination."