Latest News Releases
Updates every hour. Last Updated: 21-Sep-2025 17:11 ET (21-Sep-2025 21:11 GMT/UTC)
Inhibition of PCSK9: a promising enhancer for anti-PD-1/PD-L1 immunotherapy
ResearchPeer-Reviewed Publication
Recently, the research team led by Professor Zhang Zhongtao and Professor Yao Hongwei from the General Surgery Center at Beijing Friendship Hospital, Capital Medical University, published a review article titled "Inhibition of PCSK9: A Promising Enhancer for Anti-PD-1/PD-L1 Immunotherapy" in Research. The paper reviews the relationship between proprotein convertase subtilisin/kexin type 9 (PCSK9) and cholesterol metabolism, systematically discusses the specific mechanisms by which PCSK9 inhibition enhances anti-programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) immunotherapy, and provides a comprehensive summary and outlook on the research directions of this therapeutic strategy.
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- Research
- Funder
- National Natural Science Foundation of China, Training Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University, Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support, National Key Technologies R&D Program, Clinical Center for Colorectal Cancer, Capital Medical University, Xinjiang Uygur Autonomous Region “Tianchi Yingcai” Project
PP2A regulates CD8+ T cell effector functions through AKT signaling pathway: implications for immunotherapy
ResearchPeer-Reviewed Publication
A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune responses. The research, titled "Protein Phosphatase 2A Promotes CD8+ T Cell Effector Function through the Augmentation of CD28 Costimulation," demonstrates that PP2A serves as a critical regulator of cytotoxic T lymphocyte (CTL) activation and function.
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- Research
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- China Postdoctoral Science Foundation, National Natural Science Foundation of China, Provincial Natural Science Foundation of Zhejiang Province, Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China, Scientific Research Fund of Zhejiang Provincial Education Department
Standardized playbook for multi-material projection-based bioprinting
ResearchPeer-Reviewed Publication
The Zhejiang University team developed a multi-material projection-based 3D bioprinting (PBBP) system employing a synergistic cleaning strategy called "fluid-controlled rinsing with negative pressure-assisted capillary adsorption." Through systematic investigation of multi-material printability, they achieved standardized, high-fidelity, high-resolution printing of composite bioink structures.
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- Research
- Funder
- National Natural Science Foundation of China, Key R&D Program of Zhejiang
The gut microbiota-metabolites-brain axis mediates social behavior dysfunction
ResearchPeer-Reviewed Publication
A new study from the Air Force Medical University, China shows that Sevoflurane (Sev) influences social functioning via the gut-brain axis, with microbiota-derived bile acids serving as critical mediators in this pathway. This insight offers novel avenues for investigating the mechanisms underlying Sev toxicity and its prevention.
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- Research
- Funder
- National Natural Science Foundation of China