To address the above issues, Prof. Zhongwen Li's team at Ningbo Eye Institute, Wenzhou Medical University, introduced the Ocular Surface Pretrained Model (OSPM), a novel self-supervised learning-based domain-specific model to mitigate the scarcity of labeled data. It leverages 0.76 million unlabeled ocular surface images from 10 clinical centers across China to learn ocular surface feature representations, which can be easily adapted for classifying OSTs.

This study revealed a novel enzyme capable of degrading CAP, advancing sustainable biotechnological solutions to combat antibiotic pollution and addressing pressing environmental challenges in aquaculture and other industries worldwide.

A tiny single-celled organism may have a big impact on how the world’s basic chemical building blocks cycle between living things and the non-living environment. Called Polarella, the algal genus is a dinoflagellate that was once thought to be restricted to polar regions of Earth, but a team has revealed that it is abundant and influential in the Eastern Tropical North Pacific Ocean off the coast of Mexico.

Bladder cancer often becomes resistant to standard treatments due to its ability to evade apoptosis, the primary form of cell death targeted by conventional therapies. In a recent study, researchers from China developed a nanomedicine that triggers ferroptosis—a different cell death pathway—without needing external activation. Their proposed system not only killed resistant cancer cells but also enhanced the immune system's anti-tumor response, offering a promising dual-action therapy for bladder cancers.

The photoreaction cycle of the blue-light receptor protein BLUF domains involves forward and reverse proton-coupled electron transfer (PCET) reactions, yet a unified cross-species mechanism is lacking. By capturing the key proton relay intermediates, for the first time we resolved the photoreaction mechanism of the BLUF domain light state using a unified kinetic model.