Some of our biggest threats can come in the tiniest forms—viruses and bacteria. Thankfully, we are born with a built-in defense system, our innate immune system that protects us in our youth but can turn against us as we age. New research from the Stowers Institute for Medical Research is revealing why this tradeoff exists, identifying a common power source driving many immune system responses to pathogens. The findings may potentially lead to new ways to combat inflammation and diseases associated with aging like Alzheimer’s, Parkinson’s, and cancer.

A team from Sun Yat-sen University Sun Yat-sen Memorial Hospital has identified a novel mechanism underlying platinum resistance in triple-negative breast cancer (TNBC): the circular RNA circSCAP encodes a 129-amino-acid protein (SCAP-129aa) that activates the PI3K/AKT pathway by stabilizing PIK3R2. Silencing circSCAP or combining platinum therapy with the PIK3R2 inhibitor  significantly improved treatment efficacy in preclinical models, highlighting circSCAP and SCAP-129aa as potential biomarkers and therapeutic targets.

Researchers at The University of Osaka and Kanazawa University have developed a novel method for analyzing cancer metabolism, revealing new insights into cancer's inefficient energy process. This breakthrough, published in Metabolic Engineering, combines biological experiments with advanced information science techniques to uncover the role of cancer-specific inefficient metabolism.

A new study published in JCO Clinical Cancer Informatics demonstrates that machine learning models incorporating patient-reported outcomes and wearable sensor data can predict which patients with non–small cell lung cancer are most at risk of needing urgent care during treatment. The study was led by researchers and clinicians at Moffitt Cancer Center. 

SAN ANTONIO — September 15, 2025— Southwest Research Institute (SwRI) and The University of Texas at San Antonio (UT San Antonio) are advancing a smart biosensor coating to streamline the production of immunotherapies for cancer treatments. Researchers plan to use novel biosensor coatings to enable automated processes and reduce human errors and costs associated with their production.