EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 6-Nov-2025 06:11 ET (6-Nov-2025 11:11 GMT/UTC)

Nanoparticle blueprints reveal path to smarter medicines

University of Pennsylvania School of Engineering and Applied Science
Peer-Reviewed Publication

Researchers at the University of Pennsylvania, Brookhaven National Laboratory, and Waters Corporation have revealed that lipid nanoparticles (LNPs) — the delivery vehicles for RNA therapies — come in a surprising range of shapes and structures. Reported in Nature Biotechnology, the study shows that these structural differences directly influence how well LNPs deliver their therapeutic cargo, offering a blueprint for tailoring nanoparticles to specific diseases. The findings open the door to a new era of precision design for RNA medicines, moving beyond today’s trial-and-error approach.

Journal: Nature Biotechnology
Funder: DOE/US Department of Energy, American Cancer Society, U.S. National Science Foundation, Burroughs Wellcome Fund

Colon cancer DNA detectable in blood can guide chemo decisions: study

Walter and Eliza Hall Institute
Peer-Reviewed Publication

An international study has found a simple blood test could change how doctors decide which patients with colon cancer need chemotherapy and the patients that can be safely spared. The blood test is the result of a collaboration between Autralian medical research institute WEHI and the Johns Hopkins Kimmel Cancer Centre.

Journal: Nature Medicine

Drug which stops tumors' blood supply could help kids with bone cancer live longer

Frontiers
Peer-Reviewed Publication

Survival rates for children with multi-metastatic Ewing’s sarcoma — a kind of bone cancer which has spread to multiple parts of the body — are ‘dismal’, scientists say. The five-year survival rate for children with this cancer is very low — some studies suggest less than a quarter reach this milestone. But a small non-randomized retrospective study of a drug called pazopanib has shown that it increases children’s survival without major side-effects. 85% of patients taking the drug survived for two years after diagnosis, and two-thirds reached the end of the second year without their cancer progressing. Researchers urge the development of larger-scale trials to investigate further.

Journal: Frontiers in Oncology

First truly global picture of wide inequalities in care for women’s cancers

London School of Hygiene & Tropical Medicine
Peer-Reviewed Publication

One in five women with breast or cervical cancer in low- and middle-income countries (LMICs) are diagnosed at an early stage, compared with more than one in three in high-income countries (HICs), new research suggests. For ovarian cancer, the proportion of women diagnosed with early-stage disease was generally lower than 20% (one in five) worldwide, although the situation remains slightly worse for women in LMICs.

Journal: The Lancet
Funder: European Research Council

University of Louisville, UofL Health receive $11.5 million to develop new cancer immunotherapies

University of Louisville
Grant and Award Announcement

UofL has received $11.5 million in new funding from the NIH to support continuing research to develop therapies that activate the immune system against cancer and to train the next generation of cancer researchers and oncologists.

Funder: NIH/National Institute of General Medical Sciences

Moffitt study shows gene expression test can help identify melanoma patients at low risk of lymph node spread

H. Lee Moffitt Cancer Center & Research Institute
Peer-Reviewed Publication

A large multicenter clinical trial published in JAMA Surgery shows that a gene expression profile–based test can reliably identify melanoma patients who have a low risk of cancer spreading to their lymph nodes. The findings could help guide decisions about whether to perform sentinel lymph node biopsy, a standard but invasive staging procedure.

Journal: JAMA Surgery
Funder: SkylineDx

ESMO 2025: MSK presents new research, including latest on lung and pancreatic cancer treatments

Memorial Sloan Kettering Cancer Center
Reports and Proceedings

MSK highlights from the recent European Society for Medical Oncology (ESMO) Congress include promising findings on new lung, pancreatic, and colorectal cancer treatments and new insights for how molecular testing can guide personalized medicine.

Meeting: ESMO 25

Adding chemotherapy to radiation causes greater short-term decline in quality of life for patients with cervical cancer

University of California - Los Angeles Health Sciences
Peer-Reviewed Publication

The findings highlight the importance of providing extra supportive care during the most challenging phase of treatment—weeks three to seven—when declines in quality of life are most pronounced.

Journal: Gynecologic Oncology
Funder: NIH/National Cancer Institute, NRG Oncology

UCLA scientists develop one-product-fits-all immunotherapy for breast cancer

University of California - Los Angeles
Peer-Reviewed Publication

UCLA researchers have developed a CAR-NKT cell therapy that has shown to be more effective than current immunotherapies at fighting cancer in tumor samples from late-stage triple-negative breast cancer patients.

While personalized treatments can cost six figures and require weeks to manufacture, this therapy can be mass-produced from donated blood stem cells and stored ready-to-use at about $5,000 per dose.

The same cell product could potentially be used to treat multiple solid tumors like ovarian, pancreatic and lung cancers — all of which express the protein mesothelin.

Journal: Journal of Hematology & Oncology

New genomic test could spare some people with melanoma from lymph node biopsy surgery

Mayo Clinic
Peer-Reviewed Publication

A genomic test co-developed by Mayo Clinic and SkylineDx can identify whether people with melanoma are at low or high risk for cancer in their lymph nodes — a finding that could guide treatment decisions and help many people avoid lymph node biopsy surgery. The study results are published in JAMA Surgery.

Journal: JAMA Surgery

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