FunMap reveals a functional network of genes and proteins in human cancer
Peer-Reviewed Publication
Updates every hour. Last Updated: 7-May-2025 02:09 ET (7-May-2025 06:09 GMT/UTC)
Large-scale protein and gene profiling have massively expanded the landscape of cancer-associated proteins and gene mutations, but it has been difficult to discern whether they play an active role in the disease or are innocent bystanders. In this study, researchers at Baylor College of Medicine revealed a powerful and unbiased machine learning-based approach called FunMap for assessing the role of cancer-associated mutations and understudied proteins, with broad implications for advancing cancer biology and informing therapeutic strategies.
A team led by researchers at the Technical University of Munich (TUM) has, for the first time, grown tumor organoids – three-dimensional miniature tumors in the laboratory – that mimic the different structures and characteristics of pancreatic cancer. The scientists investigated how the various tumor organoids react to established and novel treatments. This opens the door to the development of effective new therapies.
A new review published in Blood Cancer Discovery outlines a major multiple myeloma research project that supported a key regulatory decision by a U.S. Food and Drug Administration committee. The decision greenlights a new biomarker endpoint, minimal residual disease, for accelerated drug approval in multiple myeloma, and researchers say it could cut a decade off the drug development process.
(Boston)— Nearly 2 million Americans currently reside in jails or prisons, and another 4 million are involved in the criminal legal system under forms of community supervision such as parole and probation. There is a link between incarceration and chronic health issues. The justice-involved population faces significant chronic health conditions, such as diabetes and high blood pressure, and are more likely to have cancer, infectious diseases, and substance use disorders. Approximately 95% of those incarcerated will return to the community, but are medical providers prepared to serve them?
A new study from Boston University Chobanian & Avedisian School of Medicine finds medical students and residents, nationally, are not being taught to care for the incarcerated or formerly incarcerated despite the millions of potential affected patients.