Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

The study team found that the investigational vaccine was generally well tolerated and produced an immune response in most patients. The team described the side effects of the vaccine, showed the highest tolerated dose to date, and presented the immunologic effects of the vaccine. Findings are being presented at the Society for Immunotherapy of Cancer Annual Meeting.

Chronic liver disease (CLD) is a growing global health challenge, accounting for millions of deaths each year. Its major contributors include metabolic dysfunction-associated steatohepatitis (MASH), alcoholic liver disease (ALD), and hepatitis C virus infection. These conditions are closely tied to hepatic steatosis, a condition characterized by the abnormal accumulation of fat in the liver. Recent genome-wide association studies have identified the 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) gene and its loss-of-function variant rs72613567, as a significant protective factor against CLD progression, particularly in MASH and ALD. The review highlights the importance of understanding this gene's function to unravel new therapeutic targets.

A new study by researchers at the Karolinska Institute and the University of Hamburg suggests liquid biopsy may revolutionize the detection of pancreatic incidentalomas or incidental pancreatic lesions. With the potential to offer non-invasive screening, liquid biopsy could identify high-risk patients for early intervention, potentially reducing mortality in pancreatic cancer.