Pancreatic cancer is often diagnosed at an advanced stage and is characterized by a poor prognosis and rising mortality. Galectin-3 (Gal-3), a chimeric protein, plays a multifaceted role in driving the progression of pancreatic adenocarcinoma (PAAD). While its interaction with tumor microenvironment cells is well-documented, the specific mechanisms by which Gal-3 mediates tumor–stromal interactions and promotes metabolic reprogramming linked to drug resistance remain unclear.

Researchers have extracted a novel polysaccharide fraction named AJDW from the flower of Albizia julibrissin Durazz. (AJD). AJDW could not only inhibit the growth and proliferation of pancreatic cancer in vitro and in vivo, but also suppress pancreatic cancer migration, block cell cycle and induce ROS-mediated apoptosis by reducing mitochondrial membrane potential linked to PI3K/Akt/mTOR signaling pathway.

Prof. Jiangfan Yu's team at the School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), has summarized the applications of microrobots in cancer therapy from the perspective of swarms. This review systematically discusses the design of microrobots for cancer therapy, focusing on three main strategies: tumor cell elimination, tumor infiltration, and tumor immunomodulation. Thereafter, the delivery and imaging strategies of swarms in vivo are introduced. Finally, the article summarizes current applications of microrobotic swarms across tumors in various organs and discusses the challenges and future directions to enhance cancer treatment efficiency.​