Using human cells and cutting-edge technology, the team created a three-dimensional (3D) model that accurately simulates the brain invaded by aggressive cancer. Published in Biofabrication, the study combines frontier science, advanced technology, and international collaboration — while also carrying a personal story: part of the team is formed by a couple of scientists who quite literally bring their work home.

Researchers from EMBL, the University Medical Center Mainz (UMC Mainz), and the Department of Biomedicine (Basel) have uncovered how chronic inflammation reshapes the human bone marrow environment, where blood stem cells reside, long before leukaemia emerges.

In a new study published in Nature Communications, scientists explain how they studied bone marrow samples in individuals with clonal hematopoiesis (CHIP) and myelodysplastic syndrome (MDS), observing how inflammation played a role in a cancerous progression. 

CHIP and MDS patients lose certain healthy stem-cell support cells, which are replaced by inflammatory support cells that become more common as the disease progresses, forming a self-reinforcing inflammatory loop that disrupts normal blood formation.

Overall, the research suggests that inflammatory support cells in the stem cell microenvironment play a key role in damaging the bone marrow early in disease development – potentially offering a new target for treatments that could stop blood disorders from becoming cancerous.

Our body’s “blood factory” consists of specialized tissue made up of bone cells, blood vessels, nerves and other cell types. Now, researchers have succeeded for the first time in recreating this cellular complexity in the laboratory using only human cells. The novel system could reduce the need for animal experiments for many applications.

When aggressive cancer cells spread through the body, they cause metastasis, which significantly reduces a person’s chance of survival. For this spreading to take place, they can switch between different cell states that move with different strategies. In Biomicrofluidics, by AIP Publishing, a team of researchers from the Delft University of Technology and the Kavli Institute of Nanoscience explored the mechanics at play that enable two types of metastatic cancer cells to achieve the same result of movement, with only one doing so via tissue manipulation. The research is among the first to reveal a direct link between cancer cell deformability and active migration through small gaps.

BUFFALO, NY – November 18, 2025 – A new review was published in Oncotarget (Volume 16) on November 14, 2025, titled “Mechanism of anticancer action of bifidobacterium: Insights from gut microbiota.”

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center found that patients with advanced basal cell carcinoma (BCC) may benefit from receiving immunotherapy earlier in the course of treatment. 

Radiotherapy remains one of the essential treatment modalities for brain gliomas, brain metastases, pediatric neuroblastomas, and primary central nervous system lymphomas. With continuous advancements in modern radiotherapy techniques, patients have achieved significantly improved local control rates and prolonged survival. However, the long-term complications associated with radiotherapy have become increasingly evident. Radiation-induced brain injury (RIBI) is a clinical syndrome characterized primarily by neurological dysfunction following focal or whole-brain radiotherapy. It negatively impacts patients’ quality of life and imposes a considerable burden on families and society. With the rapid development of medical imaging and artificial intelligence technologies, multimodal imaging techniques, including structural magnetic resonance imaging, diffusion-weighted imaging, functional magnetic resonance imaging, perfusion imaging, positron emission tomography-computed tomography metabolic imaging, and radiomics, have demonstrated significant potential for early detection, dynamic monitoring, and quantitative evaluation of RIBI. Meanwhile, treatment strategies for RIBI are shifting from traditional symptomatic and supportive care toward multidimensional interventions aimed at protecting the blood-brain barrier, modulating neuroinflammation, and implementing precise targeted therapies. Additionally, emerging studies have explored neuromodulation techniques and gut-brain axis regulation, offering new directions for the prevention and treatment of RIBI. Although conventional imaging methods remain valuable for diagnosing RIBI, they exhibit notable limitations in the early stages of the disease and in differentiating RIBI from tumor recurrence. This review focuses on the current state of technological development, key findings, and existing limitations, with the aim of providing a theoretical foundation and technical support for the early identification and precise intervention of RIBI.