The emerging role of SETD2 in regulating immune cell function is shedding light on potential therapeutic strategies for a range of immune-related diseases. As a key methyltransferase, SETD2 facilitates the trimethylation of lysine 36 on histone H3 (H3K36me3), a modification crucial for maintaining genomic stability and regulating gene transcription. Recent discoveries indicate that SETD2 not only influences tumorigenesis but also plays a pivotal role in the development, differentiation, and function of immune cells.

The Senator Orrin G. Hatch Proton Therapy Center, the first and only in the region, is expanding. The project will double patient capacity and enhance access to innovative radiation treatment.

Many major cancers, including those of the lung, breast and prostate gland, spread to the bones as they progress. These bone metastases are often debilitating, even deadly. They are also notoriously resistant to all kinds of treatment, including immunotherapy.

Exosomes are reshaping how scientists understand cancer progression and immune evasion. This review explores how tumor-derived exosomes orchestrate both pro-tumorigenic signaling and immune modulation within the tumor microenvironment. By highlighting their role in carrying oncogenic RNAs, reprogramming immune cells, and enabling therapy resistance, the authors present exosomes as emerging biomarkers and therapeutic vectors in the evolving landscape of cancer diagnosis and treatment.

Endometrial cancer is a common malignant tumor of the female reproductive system, and its incidence is increasing worldwide. The underlying causes of endometrial cancer are multifactorial. In recent years, the role of diet and lifestyle has received considerable attention and has become a key area of research for cancer prevention. Available literature suggests that different dietary patterns, such as the Mediterranean diet or a plant-based diet, along with moderate physical activity, are associated with a reduced risk of this cancer. Despite these findings, significant gaps in knowledge remain, particularly regarding the specific foods, lifestyle choices, and mechanisms of action that can help mitigate the risk of cancer. Furthermore, the effects of cultural and genetic differences among subpopulations make this issue even more complex. In this context, this review aimed to assess the existing literature on the potential role of diet and lifestyle factors in preventing endometrial cancer, evaluate the available data, and highlight areas that require further investigation to provide concrete evidence and recommendations for prevention.

City of Hope^® Research Spotlight offers a glimpse into groundbreaking scientific and clinical discoveries advancing lifesaving cures for patients with cancer, diabetes and other chronic, life-threatening diseases. Each spotlight features research-related news, such as recognitions, collaborations and the latest research defining the future of medical treatment.

Scientists are using artificial intelligence to enhance and accelerate treatment for glioblastoma, the deadliest brain cancer, with the goal of improving both survival time and quality of life.