EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 6-May-2025 06:09 ET (6-May-2025 10:09 GMT/UTC)

HKU researchers uncover key mechanisms driving oral cancer spread and highlight potential treatment strategies

The University of Hong Kong
Peer-Reviewed Publication

A collaborative research team from The University of Hong Kong (HKU) and West China Hospital of Sichuan University has made a breakthrough in understanding the spread of oral squamous cell carcinoma (OSCC), a prevalent and aggressive form of mouth cancer. Their findings, published in Clinical and Translational Medicine, reveal critical molecular changes that drive metastasis to lymph nodes and suppress immune responses, offering promising avenues for new treatment approaches.

Journal: Clinical and Translational Medicine

Study identifies key protein in progression of glioblastoma, a type of brain tumor

Fundação de Amparo à Pesquisa do Estado de São Paulo
Peer-Reviewed Publication

In experiments conducted at the University of São Paulo, tumor stem cells became less able to proliferate and invade tissues when the production of the prion protein was blocked by gene editing; the results suggest that the molecule could be a therapeutic.

Journal: BMC Cancer
Funder: Fundação de Amparo à Pesquisa do Estado de São Paulo

Study: suppressing key protein may unlock immunotherapy for Glioblastoma

University of Miami Miller School of Medicine
Peer-Reviewed Publication

Glioblastoma has remained one of the toughest cancers to treat, but new research suggests that suppressing a protein (ZNF638) triggers an antiviral immune response, making immune checkpoint inhibitors more effective. The discovery not only offers a potential new treatment strategy but also identifies ZNF638 as a biomarker that could help personalize immunotherapy.

Journal: Journal of Clinical Investigation
Funder: NIH/National Cancer Institute, Elsa Pardee Foundation, NIH NCI K12 Calabresi Award, UM American Can¬cer Society Intramural Funding, Florida Center for Brain Tumor Research, NREF, NIH/National Cancer Institute, NIH/National Cancer Institute, NIH/National Cancer Institute, Dwoskin Family Fund, Vivex Foundational Grant

Scientists gain insight into RNA-editing protein that could lead to improved treatment for cancer, autoimmune diseases

Rice University
Peer-Reviewed Publication

A research team led by Rice University’s Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a protein that regulates ribonucleic acid (RNA) induced immune responses. Their findings, published in Molecular Cell March 17, could open new pathways for treating autoimmune diseases and enhancing cancer immunotherapy.

Journal: Molecular Cell
Funder: Welch Foundation, Cancer Prevention and Research Institute of Texas, NIH/National Institutes of Health

Statin use and risk of hepatocellular carcinoma and liver fibrosis in chronic liver disease

JAMA Network
Peer-Reviewed Publication

About The Study: This cohort study found that statin use was associated with a reduced risk of hepatocellular carcinoma and hepatic decompensation in patients with chronic liver disease. These findings provide support for the potential role of statins in prevention of hepatocellular carcinoma and liver disease progression.

Journal: JAMA Internal Medicine

Dr. Theodore Scott Nowicki awarded $4.5M NCI grant to advance next generation of cellular immunotherapies for solid tumors

University of California - Los Angeles Health Sciences
Grant and Award Announcement

Physician-scientist Theodore Scott Nowicki, MD, PhD, an assistant professor-in-residence of pediatric hematology/oncology and microbiology, immunology, & molecular genetics at the David Geffen School of Medicine at UCLA, has been awarded a $4.5 million R37 MERIT Award to help improve the effectiveness of cellular therapies for solid tumors.

Impact journals to participate at the AACR Annual Meeting 2025

Impact Journals LLC
Meeting Announcement

BUFFALO, NY- March 17, 2025 – Impact Journals is pleased to announce its participation as an exhibitor at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2025. The meeting is scheduled for April 25-30, 2025, at the McCormick Place Convention Center in Chicago, Illinois.

Researchers receive $2.17 million grant to study noninvasive treatment for traumatic brain injury symptoms

Virginia Tech
Grant and Award Announcement

Funding from the National Institutes of Health will allow the team to investigate how a technique called cranial osteopathic manual manipulation might affect brain fluid motion and help balance the autonomic nervous system.

Newly identified bacterial protein helps design cancer drug delivery system

King's College London
Peer-Reviewed Publication

Researchers have identified a previously unknown bacterial protein, the structure of which is being used in the design of protein nanoparticles for the targeted delivery of anticancer drugs to tumors.

Journal: Proceedings of the National Academy of Sciences

Transcriptional landscape of PDAC shows distinct cell populations

Compuscript Ltd
Peer-Reviewed Publication

Pancreatic cancer is one of the leading causes of cancer-related mortality, with pancreatic ductal adenocarcinoma (PDAC) accounting for 90% of all cases. As most PDAC cases are diagnosed at advanced stages, surgical interventions are ineffective, and consequently, lymph node metastasis manifests in 70% of PDAC patients. Moreover, since the number of genetic mutations giving rise to PDAC are low, there are fewer available targeted therapeutic modalities. Analysis of gene expression at the single-cell level may help understand the tumor dynamics of PDAC.

Journal: Genes & Diseases
Funder: National Natural Science Foundation of China, National Natural Science Foundation of China, National Natural Science Foundation of China, Zhangjiang National Innovation Demonstration Zone (Shanghai, China), The Biobank Program of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (Shanghai, China)

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