Tumor cells: Disorder can promote spread
Peer-Reviewed Publication
Updates every hour. Last Updated: 3-Nov-2026 21:16 ET (4-Nov-2026 02:16 GMT/UTC)
Researchers at VCU Massey Comprehensive Cancer Center were recently awarded a $2.5 million R01 grant from the National Cancer Institute. The five-year grant will allow Massey to evaluate the efficacy of TROP2 targeted antibody-drug conjugates (ADCs) to further enhance therapeutic benefits in both breast and pancreatic cancer care.
Massey researchers, led by principal investigator Chuck Harrell, Ph.D., member of the Cancer Biology research program at Massey and professor in the Department of Pathology at the VCU School of Medicine, will look to define what enables responses and resistance to ADCs in order to identify predictive biomarkers and establish therapeutic strategies to optimize TROP2-targeted ADC efficacy in both triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC).
A groundbreaking new review article, titled “Recent advances in precise synthesis, functional modification and multidisease theranostic applications of layered double hydroxide nanomaterials,” offers a definitive roadmap for the next generation of smart nanomedicine. Published in Frontiers of Materials Science, this comprehensive study synthesizes decades of research to highlight the transformative potential of layered double hydroxides (LDHs) in treating complex diseases ranging from cancer to neurodegenerative disorders.
The metabolism of cancer cells may play a key role in their ability to evade the immune system. This is demonstrated by a new study conducted by researchers at the University of Liège, which reveals how methylglyoxal stress – a by-product of tumour metabolism – promotes immunosuppression and the formation of metastases, and may contribute to resistance to immunotherapy and the progression of triple-negative cancer.
An international team of researchers led by scientists from the University of Copenhagen and Rigshospitalet has mapped eight genetic ‘fingerprints’ that may explain why some men develop aggressive prostate cancer while others do not. The findings could eventually lead to more personalised treatment.