A newly identified centromeric structure, the CENP-A–H4 octasome, may reveal how chromosomes segregate properly during cell division, report researchers from Japan. Using cryo-electron microscopy, they visualized this complex formed only of histones CENP-A and H4, wrapped around 120 base pairs of DNA, revealing unique features important for mitosis. These findings may provide a novel perspective for understanding diseases caused by abnormal cell division, including cancer.

Researchers trace the evolutionary history of the PD-1 immune checkpoint system across jawed vertebrates, uncovering conserved features with potential relevance for cancer immunotherapy.

A new study led by experts at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, is the first to look at trends over time in alcohol-linked cancer mortality across the United States. The findings, titled “Escalating Impact of Alcohol-Related Cancer Mortality in the U.S.: A call for action,” will be presented May 31 at ASCO 2025.

A study led by University of Cincinnati Cancer Center researchers sheds new light on the mechanisms by which a major oncogene promotes and sustains lymphoma development and progression, paving the way for novel targeted therapies.

A team of researchers from MSK and Weill Cornell Medicine is expanding the understanding of how a decades-old treatment for bladder cancer works — an understanding that could help improve the effectiveness of immunotherapies more broadly.