Transforming thymic carcinoma treatment with a dual approach
Peer-Reviewed Publication
Updates every hour. Last Updated: 8-May-2025 05:09 ET (8-May-2025 09:09 GMT/UTC)
Thymic carcinoma, a rare cancer, is often associated with poor prognosis in advanced or recurrent stages. However, its rarity has delayed the development of novel pharmacotherapy. Now, researchers from Japan have evaluated the efficacy and safety of atezolizumab plus carboplatin and paclitaxel in patients with advanced or recurrent thymic carcinoma. The findings revealed that this combination exhibited a manageable safety profile and may redefine treatment strategies, offering new hope for patients with recurrent thymic cancer.
A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically summarized the interactions between aging, biological rhythms, and cancer. Their work reveals the underlying mechanisms and clinical applications in tumor biology. The findings were published in the journal of Research entitled "The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies" (Research, 2025, DOI: 10.34133/research.0612).
We’re all familiar with the outward signs of aging, such as sagging skin or thinning hair. But many age-related changes start within our cells, even our DNA, which can wear and tear over time. One creature has a way to reverse this process, at least temporarily. A hamster-sized primate from Madagascar, the fat-tailed dwarf lemur can turn back the aging clock during its annual hibernation season, according to markers of cellular aging called telomeres.