New research from Cold Spring Harbor Laboratory's dos Santos lab shows that inhibiting the BPTF protein in mice can slow or stop the spread of ER+ breast cancer and keep tumors vulnerable to common hormone therapy. The team’s findings could someday help prevent breast cancer recurrence and lead to better patient outcomes.

The ability of CD8⁺ T cells, a type of immune cell, to rapidly proliferate inside tumors is key to the success of cancer immunotherapy. In a new study, scientists from Tokyo University of Science, Japan, have identified a set of ‘signature’ genes that can determine whether these immune cells will multiply or stall within the tumor. Their findings provide a powerful pan-immunotherapy biomarker for treatment monitoring and pave the way for next-generation immunodynamic therapies.