Narwhal-shaped wavefunctions and extreme light confinement
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Dec-2025 12:11 ET (21-Dec-2025 17:11 GMT/UTC)
Apples owe much of their health value to polyphenols—natural antioxidants that fight oxidative stress and chronic diseases. Yet centuries of domestication have quietly diminished these compounds in today’s sweeter, larger fruits. A research team has now traced this nutritional loss to a specific genetic mechanism. By integrating genome-wide association analysis with molecular experiments, they uncovered a powerful regulatory pair—MdDof2.4 and MdPAT10—that triggers the accumulation of procyanidins, the most abundant polyphenols in apples. The discovery reveals how a tiny promoter insertion reawakens a dormant metabolic pathway, opening a path toward breeding apples that are both delicious and rich in health-promoting compounds.
Soybeans grown alongside maize often face shading stress that reduces yield, yet some cultivars can thrive under low light. Scientists have now uncovered a comprehensive genetic network that controls this shade tolerance, moving beyond the traditional single-gene perspective. By integrating forward genome-wide association and reverse transcriptomic analyses, researchers identified more than 200 causal genes and over 7,800 expressed genes involved in soybean’s shade response. These genes function in a coordinated sequence—from light signal detection to metabolic adaptation—forming a multilayered regulatory system. The findings open a new pathway toward breeding high-yield, shade-tolerant soybeans for intercropping systems worldwide.
An ancient genetic event may hold the key to how plants survive in metal-contaminated environments. Scientists have discovered that a duplication of phytochelatin synthase (PCS) genes—crucial enzymes for detoxifying toxic metals—occurred millions of years ago and remains conserved in flowering plants today. These twin gene copies, known as D1 and D2, evolved distinct but complementary functions: while D1 plays a general role in detoxification, D2 exhibits exceptional catalytic activity against cadmium and arsenic. Functional tests in Malus domestica (MdPCS1, MdPCS2) and Medicago truncatula (MtPCS1, MtPCS2) revealed that both copies are indispensable for maintaining metal balance, unveiling a deep evolutionary strategy for resilience.
This review focuses on how immunosenescence and inflammaging impact immune checkpoint inhibitor (ICI) efficacy and safety in older cancer patients.
Immunosenescence impairs T/NK cell function (e.g., reduced TCR diversity, CD28⁻CD57⁺ senescent T cells) and expands immunosuppressive cells (Tregs, MDSCs). Inflammaging causes inflammatory imbalance via SASP and DAMPs. Both reduce ICI efficacy and increase immune-related adverse events (irAEs).
Its innovation lies in systematically linking these age-related factors to ICI outcomes. Clinically, it suggests using SIP⁺ T cell ratio/cytokine levels to predict efficacy, and proposes a scoring system to optimize elderly patients' ICI therapy.
This review summarizes 2D (direct/indirect contact, e.g., Transwell) and 3D (cell/tissue/organoid-based, microfluidic, 3D-bioprinted) co-culture models for studying glioma-tumor microenvironment (TME) cell crosstalk (glioma with endothelial cells, neurons, immune cells, etc.).
Its innovation lies in systematically integrating diverse models and emphasizing understudied multi-cell interactions. Clinically, these models enable mechanistic research and drug screening, providing insights for developing TME-targeted therapies to improve glioma treatment efficacy.