This study uncovers a novel role of RNA G-quadruplex (rG4) structures in regulating translation and cellular senescence. By integrating ribosome profiling and rG4-RIP sequencing, the researchers reveal that rG4 structures within coding regions cause ribosome pausing, disrupt protein homeostasis, and accelerate senescence. The RNA helicase DHX9 is identified as a key factor that unwinds rG4 structures and maintains translational balance. These findings highlight rG4 stabilization as a potential driver of aging and age-related diseases, offering new therapeutic opportunities by targeting rG4 dynamics.

This review article delves into the potential of secreted proteins as therapeutic targets for treating MASLD, a global epidemic with limited pharmacological interventions. The authors highlight the diverse roles of secreted proteins in regulating glucose and lipid metabolism and discuss their dysregulation in MASLD. The review summarizes recent findings on various secreted protein families, including orosomucoid (ORM), SPARC, neuregulin (Nrg), growth differentiation factor (GDF), interleukin (IL), fibroblast growth factor (FGF), bone morphogenic protein (BMP), Isthmin-1 (Ism1), and mesencephalic astrocyte-derived neurotrophic factor (MANF).

High-entropy materials (HEMs) have attracted considerable research attention in battery applications due to exceptional properties such as remarkable structural stability, enhanced ionic conductivity, superior mechanical strength, and outstanding catalytic activity. These distinctive characteristics render HEMs highly suitable for various battery components, such as electrodes, electrolytes, and catalysts. This review systematically examines recent advances in the application of HEMs for energy storage, beginning with fundamental concepts, historical development, and key definitions. Three principal categories of HEMs, namely high-entropy alloys, high-entropy oxides, and high-entropy MXenes, are analyzed with a focus on electrochemical performance metrics such as specific capacity, energy density, cycling stability, and rate capability. The underlying mechanisms by which these materials enhance battery performance are elucidated in the discussion. Furthermore, the pivotal role of machine learning in accelerating the discovery and optimization of novel high-entropy battery materials is highlighted. The review concludes by outlining future research directions and potential breakthroughs in HEM-based battery technologies.

Solid-state phosphorescent materials with stimulus-responsive properties have been widely developed for diverse applications. However, the task of generating excited states with long lifetimes in aqueous solution remains challenging due to the ultrafast deactivation of the triplet excitons and the difficulty in regulating stimulation sites in an aqueous environment.  Here, we present a microscale rigid framework engineering strategy that can be used to modulate the phosphorescence properties of carbon nanodots (CNDs). Ultrasound-responsive phosphorescent CNDs with a lifetime of 1.25 seconds in an aqueous solution were achieved. 

Beneath our feet, an invisible world of electron exchanges quietly drives the chemistry that sustains ecosystems, controls water quality, and even determines the fate of pollutants. A new review published in Environmental and Biogeochemical Processes sheds light on how electrons travel through soils and sediments across surprisingly long distances—sometimes spanning centimeters to meters—reshaping our understanding of underground environments and offering new strategies for pollution cleanup.

A sticky, toxic by-product that has long plagued renewable energy production may soon become a valuable resource, according to a new review published in Biochar.

What if we told you that one of nature’s simplest materials—biochar, the black gold of sustainable tech—can do more than just soak up pollution? Spoiler: it can actually destroy it directly, like a microscopic superhero with an electric punch. And the best part? This isn’t sci-fi. It’s real science, just published on July 10, 2025, in Carbon Research—led by Dr. Yuan Gao from the Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology at Dalian University of Technology, China. This team didn’t just study biochar—they redefined it.

Yuanyuan Wang and Wenlei Zhu's group at Nanjing University, China, and Yuehe Lin at Washington State University, USA, recently reported the development of a three-dimensional ordered mesoporous carbon skeleton with Ni single atom support using the superlattice blotting strategy for efficient electrocatalytic hydrogen production. Firstly, they derived an ordered mesoporous framework based on finite element simulation, which is of great significance for promoting uniform gas distribution, stabilizing the gas-liquid-solid interface of nanoscale hydrophilic surfaces, and enhancing mass transfer kinetics. Then, the proposed superlattice blotting strategy integrated confined oxidation to achieve thermal stability, ligand carbonization to maintain superlattice-derived porosity, acid etching to improve hydrophilicity, high-temperature graphitization to enhance conductivity, and in-situ heteroatom doping to optimize Ni coordination for the successful preparation of a three-dimensional ordered mesoporous carbon skeleton with Ni single atom support. The resulting Ni-N₂S₂ and Ni-N₃P catalysts exhibited excellent electrocatalytic activity, reaching overpotents of 239 mV (OER, 20 mA cm⁻²) and 90 mV (HER, 10 mA cm⁻²), respectively. Ni-N₂S₂⁽⁺⁾Ni-N₃P^(-) electrolysis pairs can achieve stable electrolysis performance for more than 100 hours. This work, published in CCS Chemistry, introduces a finite element simulation guidance framework to customize three-phase equilibrium, as well as confined oxidation pathways to design highly active and durable single-atom electrocatalysts. 

A reanalysis of a one-million-year-old human skull found in China is challenging the established timeline of human evolution, and suggests a new branch of the human family tree, as well as a possible link to the mysterious Denisovans.

The synergistic system of H₃PMo₁₂O₄₀ and acetic acid enables efficient lignin depolymerization to monophenols under mild oxygen pressure (0.1 MPa O₂). H₃PMo₁₂O₄₀ delivers dual acidic/oxidative functions, while acetic acid enhances lignin solubility, stabilizes catalyst complexes, and promotes oxygen activation. Crucially, this system stabilizes C_α-hydroxyl groups to inhibit recalcitrant C–C bond formation. This work establishes an industrially promising strategy for lignin valorization through oxidative cleavage under exceptionally mild conditions.