Promoting the acceptance of clinical studies about traditional Chinese medicine (TCM) interventions by the international community is a key strategy for internationalization of TCM. However, the complexities of TCM interventions – in terms of its theories, practice patterns, and components – pose significant challenges in designing and implementing clinical studies that are well accepted by the international community. This article summarized the current status of clinical studies about TCM interventions published in international journals, explored underlying barriers to promoting their global acceptance, and discussed potential strategies for future development.

In the paper published on Science of Traditional Chinese Medicine(STCM), the authors utilized synthetic biology technology to create the first artificial herbal cell (AHC) based on a traditional Chinese medicine (TCM) formulation: Compound Danshen Yeast 1.0. This breakthrough provides foundational technology for producing TCM formulations through one-step fermentation using simple carbon sources like glucose and ethanol—eliminating the need for wild harvesting or cultivation of medicinal herbs. By harnessing synthetic biology, the team reprogrammed a single yeast strain to simultaneously synthesize three classes of active ingredients—notoginsenosides (protopanaxadiol), tanshinone diterpenoid (miltiradiene), and borneol.

Decoding cosmic evolution depends on accurately predicting the complex chemical reactions in the harsh environment of space. Traditional methods for such predictions rely heavily on costly laboratory experiments or expert knowledge, both of which are resource-intensive and limited in scope. Recently, a research team developed an innovative AI tool that predicts astrochemical reactions with high accuracy and efficiency, demonstrating that deep learning techniques can successfully address data limitations in astrochemistry. Titled “A Two-Stage End-to-End Deep Learning Approach for Predicting Astrochemical Reactions,” this research was published May 15 in Intelligent Computing, a Science Partner Journal.

To meet the demand of ultrahigh-temperature thermal insulation, a novel porous dual-phase high-entropy ultrahigh-temperature ceramic (TiZrHfNbTa)C-(TiZrHfNbTa)B₂ with outstanding merits is designed and fabricated, which has superhigh porosity, low density, high strength, low thermal conductivity, and excellent oxidation resistance. The research results provide a potential alternative for ultrahigh-temperature thermal insulation materials in aerospace field.

Ischemic stroke is a leading cause of death and disability worldwide, with many patients experiencing poor outcomes despite successful recanalization. Researchers from China and the United States reviewed how the JAK2/STAT3 inflammatory pathway contributes to ongoing brain damage after stroke. They explored the roles of brain cells and the regulation of this pathway in stroke-related inflammation. Their findings suggest that targeting JAK2 could offer a promising new treatment strategy to improve recovery and reduce long-term damage.