A new study highlights the critical role of AcrAB and OqxAB efflux pumps in ciprofloxacin resistance among Klebsiella pneumoniae clinical isolates. Researchers found overexpression of these pumps and their regulators significantly contributes to multidrug resistance, offering insights for future therapeutic strategies.

A comprehensive review by researchers at Teerthanker Mahaveer University highlights critical molecular pathways—including PKC activation, oxidative stress, and inflammatory cytokines—driving diabetic neuropathy and nephropathy. The study identifies potential therapeutic targets to combat these debilitating complications.

A groundbreaking review by researchers at Central South University highlights six critical signaling pathways—CCNE1/CDK2, MYC/CDK9, CDK4/CDK6/FOXM1, PTEN/PI3K/AKT/mTOR, AURKB, and VEGFA/VEGFR—as promising targets for osteosarcoma (OS) treatment. The study underscores the potential of network-based drug discovery to combat this aggressive bone cancer.

A study by Tianjin First Central Hospital researchers reveals the miR-451/ETV4/MMP13 signaling axis as a critical regulator of NSCLC progression. Findings show miR-451 suppression activates ETV4-MMP13, driving tumor growth and metastasis, offering new therapeutic targets.

A groundbreaking study by researchers at Zhengzhou University reveals a computational framework to identify key inflammatory genes and drug candidates for abdominal aortic aneurysms (AAA). Using single-cell RNA sequencing and molecular docking, the team pinpointed SLC2A3 as a critical target and DB08213 as a promising therapeutic compound.

A study led by researchers at the General Hospital of Western Theater Command reveals that hsa_circ_0000021 promotes cervical cancer (CC) progression by sponging miR-3940-3p and upregulating KPNA2. Findings suggest this circRNA as a potential therapeutic target for CC treatment.