In 287 Han Chinese adults with HIV-1, UGT1A1*6 was significantly associated with higher dolutegravir (DTG) trough concentrations, with homozygous carriers showing the strongest effect. Compound UGT1A1*6/*60 and UGT1A1*6/*28/*60 genotypes and low body weight were independent risk factors for elevated DTG levels. No significant associations were found between DTG trough concentrations and viral suppression or adverse effects. 

Solid tumors resist CAR cell therapy through antigen heterogeneity, poor infiltration, and an immunosuppressive microenvironment. A new review argues that oncolytic viruses and CAR cells should be co-designed as an integrated, self-amplifying therapeutic system rather than simply combined. The authors describe how oncolytic viruses can install new targets, remodel the tumor microenvironment, and deliver local immune support, outlining engineering strategies, translational challenges, and future directions for next-generation solid tumor immunotherapy.

In a study published in Science China Life Sciences, a team of researchers led by scientists at the Institute of Zoology, Chinese Academy of Sciences, provides new insights into the genetic basis of convergent gliding evolution in mammals. By comparing genomes from three independently evolved gliding mammal lineages, the researchers found that these lineages rarely share the same accelerated regulatory elements, but their candidate regulatory regions may converge on similar genes, regulatory networks, and developmental pathways associated with wing membrane (patagium), appendage and muscle development. The findings suggest that distinct regulatory changes can achieve functional convergence during the repeated evolution of complex adaptive traits.

A new review in National Science Review unveils anti-visual perception as a cross-disciplinary arms race spanning biomimetics, spectral physics, and AI. From snow leopards and dazzle camouflage to UV-to-microwave signature control and adversarial attacks on machine vision, it reveals how every advance in seeing drives new ways of hiding—offering a roadmap for next-generation camouflage, stealth, robust sensing, and trustworthy AI.