A novel combination of silybin and carvedilol is firstly confirmed to synergistically block hepatic stellate cell activation by targeting the Wnt4/β-catenin signaling pathway, and its 50:1 fixed ratio in vivo can reverse liver fibrosis in a dose-dependent manner, providing a scientific and practical experimental basis for the clinical translation of liver fibrosis therapy.

Researchers have successfully engineered an L-amino acid deaminase to overcome substrate inhibition, a major bottleneck in the biocatalytic production of phenylpyruvic acid. The study demonstrates an approximately 17-fold improvement in productivity at high substrate concentrations through strategic modification of the enzyme’s binding pocket.

Researchers have created an innovative paper-based analytical device that can detect microRNA-21—a biomarker associated with multiple cancers—using only a smartphone camera for readout, demonstrating a cost-effective platform with potential for point-of-care cancer diagnostics.

This study establishes a general design platform for narrowband emitters via precise control over molecular skeletal engineering. By directing π‑electron reorganization, aromaticity is rationally tuned from global delocalization to discrete local localization, which restricts long‑range π‑electron delocalization, suppresses vibrational coupling in the excited state, and diminishes vibronic shoulder features, thereby enabling intrinsically narrowband emission. OLED devices incorporating representative emitter achieve both exceptional color purity and high electroluminescence efficiency, with CIE coordinates that closely match the BT.2020 standard for red emission.

A highly efficient immobilized cell system for continuous production of cadaverine, a key building block for polyamide synthesis was successfully developed, which demonstrated a 19-fold improvement in catalyst productivity compared to free cells, achieving stable operation for 200 hours in a packed-bed reactor.

A method using a “green” solvent made from ethylenediamine and choline chloride is provided to restructure industrial lignin. The process significantly increases the active sites on lignin while preventing unwanted clumping, transforming a low-value byproduct of the paper industry into a viable substitute for petroleum-based materials.

A new review maps out how polymer-based electrodes could help solve persistent safety, stability, and sustainability problems in solid-state metal-ion batteries. Unlike conventional designs that rely on flammable liquid electrolytes and rigid inorganic materials, polymer electrodes offer mechanical flexibility, chemical tunability, and superior interfacial contact. The analysis synthesizes recent advances in conducting and redox-active polymers, highlighting their potential to enable all-organic solid-state batteries that are lightweight, intrinsically safe, and compatible with low-energy manufacturing. The authors also identify key design strategies—including molecular engineering, composite formation, and interface modification—that could accelerate the transition from laboratory prototypes toward practical, scalable energy storage devices.

Aiming at the problems of severe degradation and complex impurities in high-acid-value waste cooking oil, a multi-stage coupled refining process including phosphoric acid degumming, alkali refining deacidification, activated carbon decolorization/deodorization and winterization was established. Waste cooking oil was successfully converted into natural ester insulating oil meeting power industry standards, providing a new pathway for the green and high-value utilization of kitchen waste oil.

A research team led by Academician Peisong Hu from the China National Rice Research Institute has identified the key gene OsSD7, which controls seed dormancy and pre-harvest sprouting (PHS) resistance in rice. The study reveals that OsSD7 encodes an F-box protein that forms an SCF E3 ubiquitin ligase complex, targeting the jasmonate repressor OsJAZ9 for degradation, thereby relieving suppression of the ABA signaling pathway. ABA induces the transcription factor OsTRAB1, which activates OsSD7 expression. A natural SNP (3,744,951) in the OsSD7 promoter distinguishes two haplotypes: Hap A (high expression, strong dormancy and PHS resistance) and Hap G (low expression, weak resistance). The Hap A allele has been artificially selected in modern Xian varieties. Using CRISPR to convert Hap G to Hap A successfully improved PHS resistance in rice, and overexpression of OsSD7 in wheat also enhanced seed dormancy, indicating a conserved mechanism across monocot crops. This study provides valuable genetic resources for breeding PHS resistance in rice, wheat, and other cereals.