A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Dec-2025 06:11 ET (21-Dec-2025 11:11 GMT/UTC)
The endocrine system plays a crucial role in regulating physiological processes and maintaining homeostasis. While previous studies have examined aging in individual endocrine organs, a comprehensive investigation across multiple endocrine tissues at single-cell resolution has been lacking. This study established the first single-cell aging atlas of the endocrine system, revealing conserved and organ-specific aging mechanisms while identifying novel regulatory pathways.
Researchers led by Prof. XU Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, revealed the important roles of POSH phase separation and its co-condensates with SHANK2/3 in the synaptic targeting of SHANK2/3 and synaptogenesis.
Global food security is facing multiple challenges from population growth, resource constraints, and climate change. UN data shows that over one-third of global food is lost or wasted during production, circulation, and consumption, exacerbating food supply shortages while causing enormous consumption of resources such as land, water, and energy.