Epigenetic noise: Unappreciated process helps cells change identity
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Sep-2025 13:11 ET (22-Sep-2025 17:11 GMT/UTC)
When triple-negative breast cancer grows, the fat cells around it seem to shrink.
UCSF researchers have discovered that the cells of these tumors, which are among the deadliest types of breast cancer, build molecular tunnels, called gap junctions, into nearby fat cells. The tumor cells then send instructions that trigger the fat cells to release stores of energy that could feed the cancer.
An international, interdisciplinary research team led by Prof. Jakob N. Kather from the Else Kröner Fresenius Center (EKFZ) for Digital Health at TU Dresden analyzed seven independent patient cohorts from Europe and the USA using their newly developed AI model. The model detects genetic alterations and resulting tissue changes in colorectal cancer directly from tissue section images. This could enable faster and more cost-effective diagnostics in the future. For the development, validation, and data analysis of the model, experts in data and computer science, epidemiology, pathology, and oncology worked closely together. The study has been published in the journal “The Lancet Digital Health”.
“Why bother? At my age, breast cancer is the least of my worries,” says a patient in the opening vignette of “Helping Patients Make Health Care Decisions,” the latest publication from the Gerontological Society of America. This new guide equips health care providers with essential strategies to support informed, value-based decision-making with their older patients, recognizing the many factors that influence how individuals approach their health care.