A research team has uncovered a previously unrecognized mechanism that promotes cancer cell survival under therapeutic pressure. The study shows how a key enzyme in lipid metabolism, stearoyl-CoA desaturase-1 (SCD1), cooperates with an epigenetic regulator to support tumor growth.

The amount of time it takes to get biomarker results is highly dependent on how long it takes after biopsy to order the test, in some cases taking weeks just to order the tests. 

Strange “chimeric” RNA once thought to be the product of cancer is actually an important controller of women’s health, including influencing their susceptibility to infectious disease and autoimmune disorders, new research suggests. 

A team of researchers has developed a new type of imaging sensor that uses both light and sound to create detailed pictures of biological tissues. This marks the first successful use of an array of over 40 microscopic, polymer-based "microrings" to capture these types of images. It can track oxygen levels, blood flow, and how dense blood vessels are. Therefore, it is much more effective at spotting the early signs of cancer.

Paneth cell metaplasia (PCM), long viewed as a consequence of chronic inflammation in ulcerative colitis, may also help protect and repair the intestine, according to researchers at Science Tokyo. The study found that inflammation increases IL-22 signaling, which promotes PCM and the production of REG3A, a protein that helps heal the intestinal lining. The findings suggest PCM may be a protective response but should be monitored because persistent PCM could increase cancer risk.

Progesterone insensitive has long hindered fertility-preserving treatment for endometrial cancer. Now in Science Bulletin, researchers from Peking University People's Hospital and Peking University, in collaboration with Beihang University show that cholesteryl ester accumulation in the tumor microenvironment predicts response. Adding statins to standard therapy reverses progesterone insensitivity, significantly increasing the likelihood of both achieving endometrial cancer remission and preserving future fertility.

The study, published in Nature Communications, develops a new cellular model that reproduces the progression of NF1-associated tumours and enables the identification of new therapeutic opportunities.