Study defines key driver of aggressive ovarian cancer
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Jun-2025 16:09 ET (16-Jun-2025 20:09 GMT/UTC)
Researchers from the University of Michigan Rogel Cancer Center developed a new mouse model that shows CDK12 acts as a tumor suppressor to drive high-grade serous carcinoma arising in the mouse oviduct – the equivalent of human fallopian tube. A promising degrader targeting CDK12 and a related gene, CDK13, can destroy these tumors.
As recommendations suggest extending hormone-based breast cancer treatment to 10 years for some patients, a new study sheds light on whether patients are opting for it. In a study of 591 women with early stage breast cancer who completed five years of endocrine therapy, 47% decided to continue the treatment.
The research focuses on the deadliest variant of prostate cancer and lays the foundation for its molecular cataloguing.
The publication is the result of a nationwide collaborative effort among multiple research groups, coordinated by the team led by Arkaitz Carracedo.
Published in the prestigious journal Genome Biology, the study suggests that the ability of tumor cells to modify the behavior of normal cells to their advantage is a key factor in the progression of the disease.
The joint research laboratory established between CIC bioGUNE and the Basurto University Hospital has enabled the generation of a highly valuable collection of samples and molecular data for future investigations.
Polarized terahertz (THz) waves offer unique advantages for diagnostic medical imaging, but scattering mechanisms in tissue remain unclear. To address this knowledge gap, researchers from Stony Brook University developed a comprehensive model of polarized THz wave scattering from biological structures. Using simulations, tissue phantoms, and porcine skin samples as validation, they showed that microscopic tissue changes can be identified from polarization measurements, offering a promising path for the early detection of cancer.