AACR announces 2025 Scientific Achievement Award recipients
Grant and Award Announcement
Updates every hour. Last Updated: 2-May-2025 16:09 ET (2-May-2025 20:09 GMT/UTC)
Novel cancer therapy combining multi-hydroxylated fullerene (MF) nanoparticles and mTOR inhibitors triggers organelle cascade collapse in tumors, disrupting cancer cells' self-repair capacity. By synchronizing the membrane-breaking effect of MF with dual autophagy regulation, this strategy induces lysosomal rupture, mitochondrial dysfunction, and endoplasmic reticulum stress while paralyzing cellular cleanup systems. Animal studies demonstrate potent tumor suppression and high safety, leveraging cancer cells' fragile organelle networks against them. The breakthrough establishes organelle communication disruption as a new anticancer paradigm, pioneering material science-enabled therapies independent of genetic targets.
University of Cincinnati Cancer Center researchers will present abstracts at the American Association for Cancer Research Annual Meeting 2025 in Chicago.