Kyoto, Japan -- Six years before the start of the COVID-19 pandemic, an Ebola outbreak in West Africa had people fearing the possibility of a global outbreak. This was the first time many had ever heard of the virus, but since it was first identified in 1976, there have actually been more than 20 serious Ebola incidents. Thankfully, none of them had the global reach of the coronavirus.

Ebola has not been eradicated, however. This deadly virus, which causes severe hemorrhagic fever in humans and has a fatality rate of about 50%, is still at large and could thus still cause a major outbreak, unless further research finds an effective solution.

A major challenge lies in the virus' structure and regulatory mechanisms, which have remained largely unclear. In particular, scientists have long struggled to fully understand its nucleocapsid, the protein shell that plays an important role in genome replication and transcription.

Early animal studies show that a single vaccine could protect the recipient from different variants of the coronaviruses that cause COVID-19, the flu and the common cold. In addition to creating antibodies that target a specific region of the spike protein that doesn’t mutate, the vaccine removes the sugar coat from the virus that allows it to hide in the body. The researcher will present his results at the ACS Spring 2025 Digital Meeting.

When wildfires threaten communities, human health can be impacted as smoke distributes on the breeze, infiltrating various structures. To help people protect themselves and their families, researchers have developed a low-cost, durable, do-it-yourself air filtration system that works as well as more expensive HEPA filters to clear indoor air pollutants such as smoke — or possibly limit the impact of airborne disease spread. They will present their results at the ACS Spring 2025 Digital Meeting.

Ashraf Ibrahim, PhD, an investigator at The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center for more than 33 years, and Assistant Research Scientist, Yiyou Gu, PhD, at TLI for more than eight years, have been conducting research using monoclonal antibodies to address mucormycosis, a fungal infection caused by Mucorales, has high mortality rates in people with weakened immune systems and those suffering from severe trauma like burns, blast injuries or victims of natural disasters. The disease caused serious infection among COVID-19 patients treated with high doses of corticosteroids with mortality rates close to 60 percent. In the United States, there are approximately 4,000 cases per year with a rate of 200,000 in Southeast Asia where the disease is endemic to India. While vaccines and immunotherapies are available for viruses and bacteria, effective antifungal immunotherapies for mucormycosis, specifically, are lacking.