Computationally designed peptide illuminates coronavirus protease activity
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Oct-2026 15:17 ET (21-Oct-2026 19:17 GMT/UTC)
A research team has computationally designed a synthetic peptide that enables modular detection of the enzymatic activity of coronavirus 3C-like protease (3CLPro), an enzyme essential for viral replication and maturation.
Researcher have identified a sugar structure that corresponds to a component of the C. auris surface. The molecule is a manmade versoion of the same structure that is found in the fungus, and it can be specifically recognised by the immune system, binding in a way that helps to direct the immune response e specifically against the fungus.
The sugar structure serves as the basis for a vaccine candidate and for protective antibodies. In addition, the researchers used one of these antibodies to develop a prototype for a rapid test to detect multiple Candida species in a lateral flow device format – similar to those used to detect the Covid virus..
Positive-strand RNA viruses extensively remodel the cellular endomembrane system to form specialized viral replication organelles (ROs). Coronaviruses generate double membrane vesicles (DMVs) that function as platforms for viral RNA (vRNA) synthesis and protect vRNA from detection by the host innate immune system. Coronaviruses hijack the host GBF1-ARF1-COPI vesicle transport pathway to utilize Golgi-derived membranes for promoting DMV formation.
Optimal containment measures exhibit a clear threshold depending on the severity of the disease
UCLA researchers discovered that a lesser-known SARS-CoV-2 protein called nucleocapsid can amplify inflammatory signals in macrophages, immune cells that help detect viruses and coordinate the body’s early response.
Chronically infecting viruses — such as Epstein Barr, cytomegalovirus (CMV), and herpes virus — are common, and often innocuous and asymptomatic. However, emerging evidence suggests their reactivation may contribute to autoimmune disease and other chronic conditions. In a new Nature study involving 15 biomedical research institutions across the United States, Boston Children’s Hospital researchers and their collaborators have discovered that COVID-19 reactivates certain dormant viruses in hospitalized patients. These findings expand understanding of chronically infecting viruses and could inform development of strategies to combat their reactivation.
A research team led by Professor Hitoshi Yamamoto of Rissho University analyzed five years of longitudinal panel survey data collected between 2020 and 2024 and examined how vaccine-related conspiracy beliefs were associated with media skepticism during the COVID-19 pandemic. The study's results appeared in Scientific Reports on August 8, 2026.