Big data-driven brain stimulation strategy offers new hope for personalized depression treatment
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Jun-2025 16:09 ET (16-Jun-2025 20:09 GMT/UTC)
In a paper published in SCIENCE CHINA Earth Sciences, a team of researchers performed comparative analyses of the microbial ectoenzyme activities under atmospheric and in situ pressure conditions in the water column of the Mariana Trench, by conducting pressure-retaining sampling, isobaric transfer, and enzymatic assays in the Challenger Deep. It highlights the importance of pressure-retaining sampling and isobaric enzymatic assays and provides valuable insights into microbial ectoenzymatic activities in the deep ocean.
This study explores a weakly supervised bird counting method based on multimodal perception model that fuses optical image features and visual semantic cues. The method addresses challenges such as small target detection, complex backgrounds, and scale changes in ecological monitoring of optical remote sensing images without relying on detailed location annotations.
In this paper, Al, Al-Mg, Al-Si core-shell coated samples and physical mixture samples with PVDF were prepared using two different methods. The prepared samples and combustion products were characterized in terms of morphology through SEM-FIB and XRD techniques. Additionally, the combustion and energy release characteristics of the samples were evaluated through combustion performance tests, closed-volume pressure tests, and thermal analysis experiments.
Researchers comprehensively summarize existing multi-modal fusion technologies, detailing their technical specifics and applications in several key fields. Through in-depth analysis, the study highlights current technical bottlenecks and offers guiding recommendations for the future development of multi-modal research.
A study from ETH Zurich shows that premature aging disrupts bone structure and osteocyte networks in an age- and sex-dependent manner. Using the PolgA mouse model, researchers found significant declines in bone density, osteocyte morphology, and lacuno-canalicular connectivity by 40 weeks of age. Male mice exhibited more severe deterioration. Advanced imaging and computational analysis confirmed the damage. The findings position PolgA mice as a valuable model for studying cellular mechanisms underlying age-related bone loss.
MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.
Data from a randomised controlled trial of iTBS in depression (n=82) were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN. Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment. Furthermore, the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.