A collaborative research team from the University of Electronic Science and Technology of China and the Hangzhou Institute of Medicine of the Chinese Academy of Sciences, proposed a novel self-supervised reconstruction framework that decouples measurement sampling resolution from reconstruction grid density to address the trade-off between sampling and imaging in single-pixel imaging. The framework enables high-pixel-resolution reconstruction from the low-dimensional measurements, providing a new strategy for overcoming resolution limitations in conventional single-pixel imaging.

Even a local mRNA injection can produce unwanted expression in the liver. Researchers have redesigned the lipid nanoparticles that carry mRNA to reduce this spillover in mice while preserving expression in injected muscle. The formulation also supports repeated dosing and improves the confinement of expression after local brain and eye delivery.

Umbilical cord blood is more than a source of stem cells for transplantation. A review in Science China Life Sciences examines how its diverse cells and bioactive components are being explored for cancer immunotherapy, inherited disorders and tissue repair. The authors connect these opportunities with advances in cell expansion, gene engineering and manufacturing, while identifying barriers to clinical translation. They emphasize that many emerging applications still require further evidence of safety, effectiveness and durable benefit.

A recent study published in National Science Review has revealed silicate magma can store far more oxygen than its chemically allows. In high-pressure experiments, silicate melt can store up to about 5 wt.% excess oxygen, which is released as the magma rising. The findings suggest that oxygen-rich magmas could carry oxidizing power from Earth’s interior toward the surface, and may explain links between large-scale magmatism episodes and atmospheric oxidation in Earth’s history.

Aerogel fibers have been considered as a promising solution for thermal protection textiles due to their high porosity and low thermal conductivity. However, the scalable production of sustainable and mechanical strong aerogel fibers remains a critical challenge. Here, inspired by the porous core–shell structure of polar bear hair, we report a continuous strategy to fabricate all-biomass aerogel fibers featuring an encapsulated core–shell architecture using silk fibroin as the core and cellulose as the shell. This tunable structure, with radially aligned sheet-like pores and adjustable shell thickness, is achieved through hydrogen bond-driven cellulose contraction and alcohol-induced curing of sheet-like silk fibroin. Such a porous architecture effectively suppresses convective heat transfer and promotes a multi-reflective effect for infrared radiation. The resulting fibers exhibit good mechanical robustness with a tensile load of a single aerogel fiber is up to 200 g without reinforcement. Meanwhile, the aerogel fiber maintains high porosity (79.78%), low thermal conductivity (52.4 ± 4.2 mW m⁻¹ K⁻¹), and low density (0.193 ± 0.01 g cm⁻³). Furthermore, an aerogel glove fabricated from these fibers demonstrates good thermal insulation. These results provide new insights for the design of biomimetic aerogel fibers with core–shell architecture, offering a scalable and eco-friendly pathway toward advanced wearable thermal management.

Immune maturation after weaning has long been considered a one-time developmental milestone. By profiling 120,649 immune cells from 10 tissues of germ-free and microbiota-colonized mice from weaning to adulthood, researchers show that microbial signals are needed continuously: they maintain antigen-processing capacity in myeloid cells and relieve PDCD4-mediated translational repression in lymphocytes. Restoring the microbiota reversed the immune suppression, indicating that immune competence is a maintained state rather than a fixed endpoint.

The aqueous zinc metal batteries (AZMBs) are famous for high-safety and high-energy-density, but limited by severe challenges around the Helmholtz plane layer such as the strong ion–dipole interactions between Zn²⁺ and H₂O, resulting in slow desolvation processes and limited transport kinetics as well as corresponding higher barriers. To reconstruct the ion–dipole surroundings, the interface chemistry of employing a high permanent dipole moment of L-Carnosine (L-CN) has been proposed, weakening the interactions between Zn²⁺ and H₂O to realize a crowded Zn²⁺-conductive structure, accelerating the desolvation kinetics. As revealed, the strong affinity between L-CN and Zn²⁺ enables the L-CN molecules to repulse H₂O, reconfiguring the inner Helmholtz plane layer, thereby inhibiting the active water molecular to form hydrogen evolution reactions. Consequently, the Zn//Zn symmetric cells with Helmholtz plane modulation achieve a long lifespan up to 7000 h, a high Coulombic efficiency of 99.72%, and a high stabilization at high depth of discharge (85.4%). The assembled Zn//V₂O_5−x full cell with optimal electrolyte delivers the capacity of 289 mAh g⁻¹ after 500 cycles at 1 A g⁻¹ under an N/P ratio of 3.98. Impressively, the large-scale pouch cell with optimal electrolyte stabilizes for 200 cycles, offering the bright future of reconstructing Helmholtz plane for achieving high-performance AZMBs.

A nationwide ChinaHEART cohort of 4,258,033 adults found that no single obesity measure provided consistently strong discrimination across all major chronic diseases. Relatively higher discrimination was observed for the Chinese visceral adiposity index (CVAI) in cardiovascular disease, the triglyceride-glucose index (TyG) in diabetes, and the a body shape index (ABSI) in COPD, while discrimination for cancer was generally limited. All measures showed limited discrimination for cancer, supporting disease- and population-specific risk assessment beyond BMI.

Researchers have developed a novel composite hydrogel film that combines a polyacrylamide and calcium alginate polymer network with in-situ calcium carbonate mineralization. This innovative approach provides a new structural method for regulating film swelling and enabling the controlled release of phycocyanin, a bioactive pigment-protein complex known for its antioxidant and antibacterial properties. The findings, recently published by Frontiers of Materials Science, open promising avenues for advanced biomedical applications, including wound dressings and tissue engineering.

Using a two-sample Mendelian randomization approach, this study (1349 cases, 203,231 controls from the FinnGen study) examined causal associations between 16 lifestyle behaviors and potential risk factors and blepharoptosis. Genetically predicted leisure screen time was associated with higher odds of blepharoptosis, with indicative evidence for BMI and current smoking as risk factors and physical activity and smoking cessation as protective factors.