Every three seconds, one life is lost to sepsis, according to the Global Sepsis Alliance. It is a life-threatening, dysregulated immune response to infection and remains a leading cause of death worldwide. Most of these deaths are preventable with timely intervention.

Conventional culturing diagnostic methods are often slow and imprecise. The advancement of metagenomic and targeted next-generation sequencing (mNGS and tNGS) now provides rapid precision diagnostics, enabling earlier treatment.

Chinese researchers led by Prof. WANG Wenda and Prof. TIAN Lijin from the Institute of Botany have revealed a breakthrough in understanding the light-harvesting efficiency of coccolithophores.

Researchers outline a path to turn carbon dioxide into a valuable green fuel and chemical feedstock, offering a promising strategy for a circular carbon economy.

As the world faces the urgent challenges of climate change and the transition to sustainable energy, a new critical review provides a comprehensive roadmap for converting waste carbon dioxide (CO₂) and carbon monoxide (CO) into propanol, a valuable fuel and industrial chemical. Published by researchers from Korea University and the Korea Institute of Science and Technology (KIST), the review highlights innovative strategies and outlines future directions for efficient, scalable production of propanol, a vital alcohol used in fuels, chemicals, and pharmaceuticals.

Salt stress remains a critical challenge for plant growth, especially in crops like pea (Pisum sativum L.). 

The International Federation of Sports Medicine (FIMS)  & Translational Exercise Biomedicine (TEB)  for Broader Collaboration.

Researchers have created a novel, bio-based foam that integrates three advanced functions: shielding electromagnetic interference, regulating temperature, and reducing infrared visibility. This lightweight, durable material could protect sensitive electronics in electromagnetic and thermal shock and offer new solutions for camouflage technology.

Recently, a review titled "Circulating tumor cell-derived organoids: current progress, applications, and future" was published in MedComm - Future Medicine. The article systematically summarises the research progress, application scenarios, and future challenges of organoids derived from circulating tumor cells (CTCs). This study comprehensively reviews the biological characteristics of CTCs, strategies for their isolation and enrichment, optimisation techniques for in vitro culture systems, and their significance in basic research, translational medicine, and clinical applications.

We report herein the design, preparation and evaluation of a N(OMe)-linked STn antigen-based glycoconjugate vaccine, that was engineered to overcome the poor immunogenicity of the native O-glyosidic bond. In murine models, the vaccine elicited robust, long-lasting IgG antibody titers with high cross-reactivity to native STn, and potent T-cell mediated immunity characterized by IFN-γ secretion and lymphocyte proliferation. The immunization resulted in significant antitumor efficacy, including prolonged survival, reduced tumor burden, and inhibition of lung metastasis.

In a paper published in MedComm – Biomaterials and Applications, a research team from Guangzhou Medical University reports the development of a copper ion (Cu²⁺)-coordinated nanoplatform (designated as CuN) using the indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor NLG919. This carrier-free nanoplatform can efficiently encapsulate various chemotherapeutic agents (e.g., cinnamic acid, mitoxantrone, docetaxel, β-lapachone) and activate systemic antitumor immunity by inducing immunogenic cell death (ICD) and inhibiting IDO1. Using β-lapachone-loaded CuN (Lap@CuN) as a representative, the team demonstrated robust suppression of primary tumor growth and lung metastasis in mice without obvious side effects, offering a new strategy for synergistic chemo-immunotherapy.

Recently, a research team led by Prof. Yinglan Zhao and Prof. Xiao Du from West China Hospital, Sichuan University published a groundbreaking original article in MedComm-Oncology, titled "Colorectal Cancer Cells Promote de novo Glycine Synthesis for Collagen Production in Cancer-Associated Fibroblasts by Secreting TGF-β1", the study uncovers a novel metabolic crosstalk mechanism between colorectal cancer (CRC) cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME). It identifies phosphoglycerate dehydrogenase (PHGDH)—the rate-limiting enzyme in de novo glycine synthesis—as a potential therapeutic target to disrupt CAF-driven collagen deposition and inhibit CRC progression.