A real-world study of 145 resectable NSCLC patients who achieved pathological complete response after neoadjuvant chemoimmunotherapy found no significant disease-free or overall survival benefit from adding adjuvant immunotherapy. The findings suggest that patients with a pCR may not need further postoperative treatment, though larger prospective studies are required for confirmation.

Scientists at Peking University have identified a mitochondrial protein that is essential for protecting motor neurons, offering new insight into how amyotrophic lateral sclerosis (ALS) may develop. The study, led by Dr. Xianhua Wang and Dr. Heping Cheng at the College of Future Technology, Peking University, shows that loss of the mitochondrial protein ROMO1 causes progressive damage to motor neurons and muscles in mice, closely resembling key features of human ALS. The findings were published online in Science Bulletin.

A research team led by Prof. Yi Sun at Zhejiang University, reported a unexpected finding that the combination of Kras^G12D activation and genetic inactivation of UBE2M in the lung triggers the cGAS-STING-NF-κB signal to form a inflammatory tumor microenvironment (TME). Mechnistically, Kras^G12D promotes the mitochondrial biogenesis, whereas UBE2M depletion inhibits Parkin neddylation and mitophagy, together causing the cytoplasmic release of damaged mitochondrial DNA. The STING antagonist H-151 rescues TME, indicating a causal role of the cGAS-STING signal. The study therefore demonstrates a unexpected role of UBE2M in prevention TME induced by Kras mutant.

Prolonged health uncertainty does not always stay in clinics or medical appointments. It can become part of everyday life, shaping work, relationships, identity, and the ability to imagine the future even when a person continues to function outwardly.

In a new analytic autoethnography, Mehmed Zahid Çögenli examined his own experience of living and working through prolonged health uncertainty. The analysis drew on approximately 1,150 lines of contemporaneous reflective writing, together with retrospective accounts and selected self-narrative documents, and used the concept of biographical disruption to understand how uncertainty entered ordinary life.

Four connected themes were identified: health uncertainty beyond the clinic; carrying competence under strain; silence, disclosure, and institutional vulnerability; and rebuilding a livable future. The study argues that continued productivity can conceal substantial invisible effort, and that prolonged uncertainty can become an occupational and relational burden even before medical clarity is reached.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant morbidity, yet the mechanisms driving organ damage remain incompletely understood. In a new review published in Rheumatology & Autoimmunity, researchers from Kunming Medical University synthesize single-cell transcriptomic and mechanistic evidence to propose Granzyme K (GZMK) as a critical pathogenic node in SLE, particularly in lupus nephritis (LN). The review challenges the traditional view of granzymes as purely intracellular cytotoxic molecules and presents GZMK as a multifaceted extracellular mediator that activates complement, drives inflammation, and disrupts vascular integrity.