We report herein the design, preparation and evaluation of a N(OMe)-linked STn antigen-based glycoconjugate vaccine, that was engineered to overcome the poor immunogenicity of the native O-glyosidic bond. In murine models, the vaccine elicited robust, long-lasting IgG antibody titers with high cross-reactivity to native STn, and potent T-cell mediated immunity characterized by IFN-γ secretion and lymphocyte proliferation. The immunization resulted in significant antitumor efficacy, including prolonged survival, reduced tumor burden, and inhibition of lung metastasis.

In a paper published in MedComm – Biomaterials and Applications, a research team from Guangzhou Medical University reports the development of a copper ion (Cu²⁺)-coordinated nanoplatform (designated as CuN) using the indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor NLG919. This carrier-free nanoplatform can efficiently encapsulate various chemotherapeutic agents (e.g., cinnamic acid, mitoxantrone, docetaxel, β-lapachone) and activate systemic antitumor immunity by inducing immunogenic cell death (ICD) and inhibiting IDO1. Using β-lapachone-loaded CuN (Lap@CuN) as a representative, the team demonstrated robust suppression of primary tumor growth and lung metastasis in mice without obvious side effects, offering a new strategy for synergistic chemo-immunotherapy.

Recently, a research team led by Prof. Yinglan Zhao and Prof. Xiao Du from West China Hospital, Sichuan University published a groundbreaking original article in MedComm-Oncology, titled "Colorectal Cancer Cells Promote de novo Glycine Synthesis for Collagen Production in Cancer-Associated Fibroblasts by Secreting TGF-β1", the study uncovers a novel metabolic crosstalk mechanism between colorectal cancer (CRC) cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME). It identifies phosphoglycerate dehydrogenase (PHGDH)—the rate-limiting enzyme in de novo glycine synthesis—as a potential therapeutic target to disrupt CAF-driven collagen deposition and inhibit CRC progression.

Entangled photon pairs enable several quantum imaging techniques. However, a spatial phase aberration can degrade the image quality. To develop a more efficient biphoton phase measurement method, researchers in China proposed position-correlated biphoton Shack–Hartmann wavefront sensing. By using a microlens array, the phase pattern added to biphotons with a strong position correlation can be reconstructed after a single-shot joint probability measurement. This method holds great potential in future real-time quantum adaptive imaging researches.

Scalable fabrication of efficient wide-bandgap (WBG) perovskite solar cells (PSCs) is crucial to realize the full commercial potential of tandem solar cells. However, there are challenges in fabricating efficient methylammonium-free (MA-free) WBG PSCs by blade coating, especially its phase separation and films stability. In this work, an MA-free WBG perovskite ink is developed for preparing FA_0.8Cs_0.2Pb(I_0.75Br_0.25)₃ films by blade coating in ambient air. Among various A-site iodides, RbI is found to be the most effective in suppressing the precipitation of PbI₂ induced by Pb(SCN)₂ while keeping the enlarged grains. The distribution of Rb suggested that the Rb ions are kept isolated with the perovskite grains during the crystallization and Ostwald ripening processes, which contributes to the formation of the large-grain WBG perovskite film with minimum non-radiative recombination. As a result, a power conversion efficiency (PCE) of 23.0% was achieved on small-area WBG PSCs, while mini-modules with an aperture area of 10.5 cm² exhibited a PCE of 20.2%, among the highest reported for solar cells prepared with WBG perovskites via blade coating. This work presents a scalable and reproducible fabrication strategy for stable MA-free WBG PSCs under ambient conditions, advancing their path toward commercialization.

Refractory wounds cause significant harm to the health of patients and the most common treatments in clinical practice are surgical debridement and wound dressings. However, certain challenges, including surgical difficulty, lengthy recovery times, and a high recurrence rate persist. Conductive hydrogel dressings with combined monitoring and therapeutic properties have strong advantages in promoting wound healing due to the stimulation of endogenous current on wounds and are the focus of recent advancements. Therefore, this review introduces the mechanism of conductive hydrogel used for wound monitoring and healing, the materials selection of conductive hydrogel dressings used for wound monitoring, focuses on the conductive hydrogel sensor to monitor the output categories of wound status signals, proving invaluable for non-invasive, real-time evaluation of wound condition to encourage wound healing. Notably, the research of artificial intelligence (AI) model based on sensor derived data to predict the wound healing state, AI makes use of this abundant data set to forecast and optimize the trajectory of tissue regeneration and assess the stage of wound healing. Finally, refractory wounds including pressure ulcers, diabetes ulcers and articular wounds, and the corresponding wound monitoring and healing process are discussed in detail. This manuscript supports the growth of clinically linked disciplines and offers motivation to researchers working in the multidisciplinary field of conductive hydrogel dressings.

A new study published in Frontiers in Energy employs a "segmented voltage monitoring method," which integrates voltage leads into three series batteries within the SOEC stack, enabling the quantitative separation of degradation contributions from the cell body and the interconnect-cell interface, thereby providing direct experimental evidence for optimizing stack design.

Huang Feihe at Zhejiang University, Jonathan Sessler of the University of Texas at Austin, and colleagues reported a novel cation recognition mode which mimics the biological allosteric effect and achieves efficient recognition of cations by cationic compounds. This work, published in CCS Chemistry, achieves continuous recognition of anions and cations by synergizing various recognition modes while also utilizing the allosteric effect during the recognition process to explore a new cation recognition mode.

In a pioneering study that combines advanced technology with agricultural practices, researchers are exploring how capacitance-enhanced biochars can significantly increase the removal of ginsenoside Rb1 from soils. The study, titled "Increased Removal of Ginsenoside Rb1 Through the Application of Capacitance-Enhanced Biochars in Soils," is led by Prof. Bo Pan from the Yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control at Kunming University of Science & Technology in Kunming, Yunnan, China. This research offers valuable insights into sustainable soil management and the potential of biochars in addressing soil contamination.

Scientists in China have created a new material that makes Chinese spirits taste better—while also helping the environment. The breakthrough could give new life to distiller’s grains, the massive amount of by-product left behind in liquor production.