Peri-centrosomal localization of small interfering RNAs in C. elegans
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Apr-2025 20:08 ET (1-May-2025 00:08 GMT/UTC)
Centrosomes are nonmembrane organelles and responsible for microtubule nucleation and organization. Centrosomal RNAs have been identified in diverse model systems and are known to regulate gene expression during cell division in many species. However, whether and how centrosomal RNAs exist in C. elegans and, if yes, their functions and mechanisms remain unclear. A recent study published in SCIENCE CHINA Life Sciences explored the potential presence and biogenesis of peri-centrosome localized small interfering (si)RNAs in C. elegans by utilizing the nuclear RNAi Argonaute protein NRDE-3 as a reporter. The findings suggest that the peri-centrosomal region may serve as a platform for RNAi-mediated gene regulation, offering new insights into centrosomal (si)RNAs.
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