A novel machine learning framework accelerates the discovery of ionic thermoelectric materials, achieving precise Seebeck coefficient predictions. This groundbreaking method identified a waterborne polyurethane-potassium iodide ionogel with a Seebeck coefficient of 41.39 mV/K. Insights into key molecular features promise rapid advancements in waste-heat recovery and thermal sensing technologies.

In a paper published in Science Bulletin, Researchers discovered a unique signature of the planar Hall effect (PHE) in magnetic Weyl semimetals, where PHE conductivity is determined by a global quantity: the Chern number of Weyl point. Due to the robustness of the Chern number, the PHE conductivity here is independent of many material details, leading to a planar Hall plateau, which is rare and has great potential applications. By revealing completely new physical signatures, their work significantly advances the field of Hall transport.

In a paper published in National Science Review, an advanced catalytic team of scientists present a novel heterogeneous catalytic process that efficiently converts polyurethane waste into important chemicals like aromatic amines and lactones by combining methanolysis and hydrogenation with a CO₂/H₂ reaction medium. The intermediate chemicals were then transformed into functional polymers—polyimide and polylactone.

This study, led by Prof. Bin Du, Li Weng, and Hongda Chen from Peking Union Medical College Hospital, examines the rising burden of sepsis among hospitalized cancer patients in China from 2017 to 2019. Sepsis, a serious condition caused by infection-related inflammation, is a leading cause of death in cancer patients. The study found a 35.3% increase in sepsis incidence, from 4111.20 to 5564.42 per 100,000 admissions. Sepsis-related mortality also rose by 53%, with higher rates in older patients, especially those aged 85 and above. The study highlights the need for focused interventions on infection prevention, early detection, and timely management to reduce sepsis-related mortality, especially in regions with limited healthcare resources.

A research team led by Professors Wu and Cai at the State Key Laboratory of Transducer Technology, AIRCAS has developed a flexible serpentine electrode probe that enables stable, long-term neural monitoring. This study was published in National Science Review.

SETD2 is the only enzyme responsible for transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3). Mutations in SETD2 cause human diseases including cancer and developmental defects. In mice, Setd2 is essential for embryonic vascular remodeling. Given that many epigenetic modifiers have recently been found to possess noncatalytic functions, it is unknown whether the major function(s) of Setd2 is dependent on its catalytic activity or not. Here, we established a site-specific knockin mouse model harboring a cancer patient-derived catalytically dead Setd2 (Setd2-CD). We found that the essentiality of Setd2 in mouse development is dependent on its methyltransferase activity, as the Setd2^CD/CD and Setd2^−/− mice showed similar embryonic lethal phenotypes and largely comparable gene expression patterns. However, compared with Setd2^−/−, the Setd2^CD/CD mice showed less severe defects in allantois development, and single-cell RNA-seq analysis revealed differentially regulated allantois-specific 5′ Hoxa cluster genes in these two models. Collectively, this study clarifies the importance of Setd2 catalytic activity in mouse development and provides a new model for comparative study of previously unrecognized Setd2 functions.

This study investigates the structural and functional alterations in cerebellar outputs in an autism mouse model (Nlgn3^R451C). The researchers used large-scale circuit tracing to map the projections from cerebellar nuclei to the thalamus, midbrain, and brainstem, identifying specific changes in innervation patterns. They also demonstrated that chemogenetic inhibition of a specific neuronal population in the zona incerta (ZI) could rescue social deficits in these mice.

Researchers from Beijing Normal University and Nanjing University have developed a new genetically encoded calcium indicator (GECI) called TurCaMP, which offers bright cyan fluorescence and minimal interference from physiological pH fluctuations. This breakthrough opens new possibilities for studying calcium signaling in mitochondria, a key player in cellular energy metabolism and calcium homeostasis.