Glucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stability
Peer-Reviewed Publication
Updates every hour. Last Updated: 5-May-2025 19:09 ET (5-May-2025 23:09 GMT/UTC)
In this study, the researchers first conducted a whole-genome CRISPR-Cas9 screening to identify upstream regulators of PINK1-Parkin-mediated mitophagy. Among several hundreds of positive hits, they focused on one important enzyme, glucose-6-phosphate dehydrogenase (G6PD), which is a rate-limiting enzyme in the pentose-phosphate pathway (PPP), an essential process in glycolysis.
Imagine the deep frustration of countless men who long to become fathers, only to face infertility due to a genetic condition they can't control. For those with Klinefelter syndrome, this painful reality is a constant struggle.
How does an extra X chromosome lead to infertility in men? Professor Qiao Jie and her team at Peking University Third Hospital revealed why Klinefelter syndrome, a common genetic condition affecting one in every 600 men, often leads to infertility—and they’ve identified a potential way to treat it. Their research, titled “How the extra X chromosome impairs the development of male fetal germ cells,” published in Nature Cells (DOI: 10.1038/s41586-024-08104-6) provides new insights into the molecular mechanisms at play and even offers potential treatment avenues.