A study of 13,126 participants from the UK Biobank found that individuals diagnosed with diabetes after age 50 had a lower risk of all-cause dementia compared to those diagnosed before 50. The protective effect was strongest among those with high genetic risk for dementia or carrying the APOE ε4 allele. These results highlight the importance of early diabetes management and personalized prevention strategies for high-risk groups.

Helical pulses, shaped like flying electromagnetic conches, long predicted but never directly observed, have now been experimentally realized in both optical and microwave bands. The work shows that light can twist through space and time within a single cycle, forming truly space time nonseparable wave packets. This breakthrough confirms a decades old theoretical prediction and opens new paths for ultrafast communication, topological field control, and advanced imaging.

A research team from the Songshan Lake Materials Laboratory has developed an AI-guided "Recommendation System" to discover new metallic glasses (MG). By combining element embeddings learned from Wikipedia by a language model with graph neural networks analyzing hidden material relationships. This approach addresses longstanding challenges related to the vast chemical space and limited experimental datasets, opening new horizons for materials design and accelerating the development of next-generation MGs.

Schematic of the early-stage characteristics of house dust mites-induced bronchial fibroblasts, which are characterized by suppressed extracellular matrix production alongside activated inflammatory signaling.

Liver cancer remains a significant global health challenge with limited effective treatments. A new study published in Med Research utilizes multiomics analysis to reveal how the traditional medicinal plant Lobelia chinensis Lour (LCL) exerts potential anticancer effects. Researchers identified specific bioactive components in LCL that target key cell cycle proteins—CCNB1, CCNB2, and CDK1—thereby inhibiting tumor progression. These findings highlight the therapeutic potential of LCL and suggest new diagnostic markers for liver cancer prognosis.

Researchers have developed DrugtargetMR, a comprehensive computational tool designed to bridge the gap between genetic discoveries and clinical applications. By integrating multi-omics data with advanced statistical modeling in a unified R framework, the software simplifies the identification of causal genes and therapeutic targets for complex human traits, making sophisticated post-GWAS analysis accessible to the broader scientific community.

Researchers have published a comprehensive review exploring the critical role of the "immune microenvironment" in the progression of major chronic diseases. The study details how interactions between immune cells, cytokines, and the extracellular matrix contribute to conditions such as diabetes, cardiovascular disease, and cancer. The review emphasizes that targeting this microenvironment offers promising new avenues for diagnosis and immunotherapy, potentially shifting the paradigm of chronic disease management.

 

A new review article published in Med Research explores the application of microcalorimetry to measure the "four properties" (cold, hot, warm, and cool) of Traditional Chinese Medicine (TCM). By interpreting these ancient concepts through modern thermodynamics and biological heat monitoring, researchers propose a standardized, scientific framework called the "Stylization of TCM" to enhance quality control, clinical safety, and international acceptance.