Researchers from DICP developed a highly sensitive proteomics method called peptide-centric local stability assay (PELSA), which enables the simultaneous identification of ligand-binding proteins and their binding sites in complex systems. PELSA is broadly applicable to diverse ligands including metabolites, drugs, and pollutants.

Researchers have developed a new aluminosilicate zeolite, ZMQ-1, which features a unique intersecting meso-microporous channel system that is expected to enhance catalytic processes in the petrochemical industry.

Researchers from Osaka Metropolitan University have developed nanofluidic devices capable of manipulating single nanoscale objects, including DNA, nanoparticles, proteins, and small molecules in solution. They introduced "nanofluidic manipulation," enabling precise nanoscale control. In a review article, they highlighted advancements, challenges, and the transformative potential of this emerging field for integrating scientific fields and driving innovation.

In a surprising development in the field of robotics, researchers have discovered that small modifications to a robot’s body mass and ball size can significantly enhance its balancing abilities.

Microwave dielectric ceramics, as the core component of fabrication of passive electronic devices, are widely used in numerous fields such as filters, dielectric antennas, and microwave communications . For high-frequency communication, microwave dielectric ceramics with low relative permittivity (ε_r) are preferable due to their ability to decrease signal latency and facilitate the manufacturing of passive components. Additionally, microwave dielectric ceramics that are ideal for making passive components should have a temperature coefficient of resonance (τ_f) as near to zero as feasible and a high quality factor (high Q×f, that is, low dielectric loss tanδ = 1/Q). Vanadium-based zircon ceramics hold potential application prospects in the next generation of wireless communications due to their low dielectric constant and adjustable temperature coefficient of resonant frequency at microwave frequencies. However, achieving ultra-low dielectric loss still poses a significant challenge.

A research team conducted a study to improve robots' performance in multiple peg-in-hole assembly in adapting to different working scenarios, including different object geometry and pose. Using a flexible and reusable sequential control policy framework, they explored how to apply artificial intelligence technology more efficiently in industrial scenarios. Their sequential control policy framework demonstrated higher training efficiency with faster convergence and a higher success rate compared to the single control policy for long-term multiple peg-in-hole assembly tasks.

On December 4, 2024, Journal of Intelligent and Connected Vehicles (JICV) was officially included in the Emerging Sources Citation Index (ESCI).

The host antimicrobial immune response relies on a complex interplay of molecular mechanisms to effectively combat microbial infections. Herein, we investigate the functional role of Cullin-3 (Cul3), one critical constituent of cullin-RING ubiquitin ligases, in the Drosophila melanogaster (fruit fly) antimicrobial immune defense. We show that silencing of Cul3 leads to a decreased induction of antimicrobial peptides and high mortality in adult flies after bacterial infection. Through biochemical approaches, we demonstrate that Cul3 predominantly relies on its BTB-binding domain and neddylation domain to physically associate with death-associated inhibitor of apoptosis 2 (Diap2). Importantly, Cul3 ameliorates the Diap2-mediated ubiquitination of death-related ced-3/Nedd2-like caspase (Dredd), a process essential for robust immune deficiency signaling upon bacterial infection. Taken together, our findings highlight a previously unrecognized regulatory axis of Cul3/Diap2/Dredd in the fly antimicrobial immune defense, providing potential insights into therapeutic strategies for combating bacterial infections in humans.

A cutting-edge study has uncovered crucial new insights into the effects of equatorial plasma bubbles (EPBs) on aircraft navigation systems, shedding light on the hidden dangers posed by these atmospheric phenomena.

A critical study sheds light on the growing global burden of esophageal cancer, outlining its significant impact and the imperative to identify the driving factors behind its increasing prevalence.