A research team has computationally designed a synthetic peptide that enables modular detection of the enzymatic activity of coronavirus 3C-like protease (3CLPro), an enzyme essential for viral replication and maturation. 

A research team has found that dyadic coping—the way couples jointly manage stress—partly explains the association between fear of cancer recurrence and depression among middle-aged and older survivors of gastrointestinal cancer. 

Duraplasty is a surgical procedure that is used to repair or reconstruct the dura mater using a patch graft. Several graft materials are used for the surgery, but their comparative safety remains uncertain. Now, researchers conducted a prospective randomized study in Central India to compare the outcomes of autologous pericranium (natural graft) with those of synthetic high-density polypropylene (G-Patch) in patients undergoing cranial duraplasty. Findings confirmed that both materials demonstrated acceptable short-term safety profiles.

A study in Chinese Medical Journal reports that SLC38A7, a lysosomal glutamine transporter, is overexpressed in gastric cancer and associated with poor prognosis. Using patient tissues, cell models, mutational analyses, and mouse xenografts, the researchers show that SLC38A7 binds MYH9, promotes GSK-3β ubiquitination and degradation, and activates Wnt/β-catenin signaling. The findings identify a metabolically linked oncogenic pathway, clarify a previously unrecognized disease mechanism, and suggest a potential therapeutic target for gastric cancer.