USTC achieves breakthrough in functional protein design with deep generative models
Peer-Reviewed Publication
Updates every hour. Last Updated: 4-May-2025 02:10 ET (4-May-2025 06:10 GMT/UTC)
Researchers from the University of Science and Technology of China (USTC), led by Prof. LIU Qi, in collaboration with Harvard Medical School’s Marinka Zitnik lab, have developed a novel deep generative algorithm, PocketGen. This algorithm, based on graph representation learning and protein language models, efficiently generates protein pocket sequences and spatial structures for binding small molecules. The study was published in Nature Machine Intelligence.
Recently, a team of international scientists led by Prof. JIAN Zhang from the University of Science and Technology of China (USTC) has made a significant breakthrough in understanding Mars' radiation environment. The research team focused on the solar energetic particle event (SEP) that occurred on February 15, 2022, and reconstructed the energy spectrum of this event for Mars for the first time. The study was published in Geophysical Research Letters.
A research team led by Prof. KANG Yanbiao from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences has made a significant discovery in the field of environmental chemistry. They developed a novel photocatalyst named KQGZ, which can photocatalytically defluorinate polyfluoroalkyl and perfluoroalkyl substances (PFASs) at a low temperature range of 40 - 60°C. This finding has been published in Nature.
A research team led by Prof. CUI Songlin at University of Science and Technology of China (USTC), in collaboration with Prof. ZHOU Meng's team from Beijing Information Science and Technology University (BISTU) has proposed a new strategy for designing pure-red organic light emitting diodes (OLED) materials. These materials have achieved a milestone with electroluminescence efficiencies exceeding 43%, marking a significant step towards high-performance ultrahigh-definition OLED displays. The study was published online in the Journal of the American Chemical Society.
Researchers at the Institute of Modern Physics (IMP) of the Chinese Academy of Sciences, together with their collaborators, have achieved the first precise mass measurements of several exotic atomic nuclei. Using this mass data, they have determined the proton dripline for the elements aluminum, phosphorus, sulfur, and argon, and have proposed a new approach to uncovering proton halo structures.
The paper explores the unique properties of optically active crystals with screw symmetries. These crystals exhibit nonlocal super-dispersion, meaning their polarization rotation properties strongly depend on the wavelength. This nonlocal response allows for the development of a novel camera, the "Nonlocal-Cam." Unlike traditional cameras, the Nonlocal-Cam captures the spectral and polarimetric components of light, providing additional information about the scene. This technology has potential applications in various fields, including biology, machine vision, and remote sensing.
A pivotal study unveils a novel approach to combating gray mold, a devastating pathogen for grapevines.
Scientists are making waves with a novel therapy for metastatic colorectal cancer (mCRC) that combines two powerful antibodies—one targeting epidermal growth factor receptor (EGFR), the other programmed cell death 1 (PD-1).