MXene-based hydrogel disrupt bacterial biofilms and reprogram immune cell metabolism to reverse bone resorption in periodontitis
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Oct-2026 13:16 ET (28-Oct-2026 17:16 GMT/UTC)
Researchers in Lin Quan's research group at Jilin University have developed an injectable MXene-based hydrogel specifically for treating periodontitis. This hydrogel, named GQM, consists of oxidized gellan gum, quaternized chitosan, and magnesium-tannic acid-modified MXene nanosheets. It can be injected into periodontal pockets, overcoming the problem of traditional drugs' inability to remain within these pockets. Under near-infrared light irradiation, it can gently disrupt bacterial biofilms through photothermal activity, while the electrostatic effect of the QCS (quaternary cytosolic crystals) helps kill periodontal pathogens. Furthermore, the nanosheets promote electron transport, restore mitochondrial NAD+/NADH balance, and induce macrophages to transform into the M2 type. In a rat model of periodontitis, GQM combined with near-infrared light therapy reduced bacterial count, inflammatory response, and alveolar bone resorption. The MXene-based hydrogels treat periodontitis by disrupting bacterial biofilms and reprogramming immune metabolism, offering a novel strategy for its management.
Steric hindrance of long-chain ligands leads to abundant unpassivated dangling bonds on quantum dots (QDs), which significantly impair the efficiency and operational stability of QD light-emitting diodes (QLEDs), especially in ultra-small pixel devices. Professors Fushan Li and Hailong Hu at Fuzhou University have pioneered a "ligand reconstruction" strategy using zirconium acetylacetonate (Zr(acac)4) to precisely repair the surface defects of QDs. This reconstruction strategy markedly enhances the efficiency and operational stability of QLEDs, and the resultant record-breaking performance metrics lay a solid foundation for the commercialization of high-resolution, high-performance QLED technology.
A research team has shown that particle diameter plays a greater role than length in controlling heat transfer through large cylindrical birchwood samples during torrefaction.
A research team has developed a chitosan-modified, phytic acid-doped polyaniline (CS/PA-PANI) electrode that rapidly and selectively captures uranium from aqueous environments through capacitive deionization.
A network meta-analysis of 24 trials involving 744 participants has identified vertically resisted plyometric training as the most effective method for enhancing change-of-direction speed. The Bayesian analysis, led by Jishou University and the University of Freiburg, ranked this approach above nine other modalities, with vertically resisted sprint training second. Notably, the turning angle did not affect outcomes, suggesting that resisted training adaptations transfer across all directional changes.
This research shows a new way to control light at extremely high speeds using ultra-thin silicon metasurfaces. By carefully designing how light passes through them, the team achieved strong and fast control over a wider range of colours than previously possible. This breakthrough helps overcome a key limitation in current technology and could support faster internet, improved data processing, and future light-based computing systems.
A research team has developed a sustainable method for converting biomass and nitrogen-rich polyurethane (PU) waste into nitrogen-doped hierarchical porous carbon for aqueous zinc-ion hybrid capacitors (ZIHCs).
Caloric restriction (CR) is an effective dietary intervention that delays aging and improves metabolic health. Previous studies have reported that lithocholic acid (LCA), a secondary bile acid, increases significantly in serum during CR. LCA has been shown to mimic the anti-aging effects of CR across multiple model organisms, including elevating muscle NAD+ levels, enhancing grip strength and exercise endurance in aged mice, and extending lifespan in nematodes and fruit flies.
The discovery of twisted graphene moiré superlattices has opened new avenues for exploring low-dimensional quantum states of matter. This review summarizes recent experimental and theoretical advances in twisted graphene systems, focusing on electron correlation, unconventional superconductivity, and topological states emerging from moiré flatbands, while highlighting their underlying mechanisms, characterization techniques, key open questions and future research directions.
Electrochemical chloride ion removal is essential for clean water and environmental protection, yet its practical application is hindered by the sluggish kinetics, especially using high-mass-loading electrodes. Conventional extrinsic modifications, such as conductive additives or structural design, exhibit constrained effectiveness. Here, we report an intrinsic enhancement strategy through heteroatom doping-induced dual defects engineering, demonstrated by the successful synthesis of fluorine-doped copper(I) phosphide with phosphorus vacancies (F-Cu3PV) via molten salt treatment. Based on density functional theory calculations and experimental results, F doping caused lattice distortion, generating P vacancies to form dual defects. These defects effectively modulated intrinsic electron redistribution, resulting in improved electrical conductivity, enhanced adsorption capability, and reduced chloride ion diffusion energy barriers. Therefore, electron transfer and ion diffusion kinetics were significantly accelerated, leading to superior electrochemical performance. Resultantly, the F-Cu3PV electrode performed exceptional electrochemical chloride ion removal performance with superior areal deionization capacity (3.16 ± 0.02 mg cm−2) and a remarkably rapid areal deionization rate (0.106 ± 0.001 mg cm−2 min−1), as well as outstanding cycling stability (95.65% retention after 70 cycles). This work elucidates electron redistribution via heteroatom doping-induced dual defects as a viable pathway to overcome the intrinsic kinetic bottleneck for high-performance electrochemical chloride ion removal.