From vaccines to AI: how China is driving cervical cancer control
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Oct-2025 15:11 ET (28-Oct-2025 19:11 GMT/UTC)
Chronic stress fuels cancer by releasing stress mediators that remodel the tumor and stromal cells, promoting immune evasion, angiogenesis, and metastasis. A review in Science Bulletin underscores how blocking this signaling could improve outcomes and proposes stress management as a potential component of precision oncology.
Analysis revealed that ignition occurred during the development stage of the thunderstorm—not the mature stage as traditionally thought. The lightning frequency and intensity were lower in this phase, but the discharge characteristics were unique.
This study employs a quantile vector autoregression (QVAR) approach to investigate systemic risk interconnectedness across eight major NFT assets. The analysis reveals NFT markets exhibit moderate interconnectedness during normal conditions that significantly intensifies during extreme market states, creating vulnerability to volatility cascades. Research demonstrates asymmetric spillover patterns with frequent role reversals between risk transmitters and receivers, particularly when assets occupy opposite extreme quantiles. These findings provide crucial insights for constructing resilient NFT portfolios and developing effective regulatory frameworks addressing tail-risk events in digital asset markets.
Micro-sized anatase TiO2 displays inferior capacity as cathode material for magnesium ion batteries because of the higher diffusion energy barrier of Mg2+ in anatase TiO2 lattice. Herein, we report that nanosized anatase TiO2 exposed (001) facet doubles the capacity compared to the micro-sized sample ascribed to the interfacial Mg2+ ion storage. First-principles calculations reveal that the diffusion energy barrier of Mg2+ on the (001) facet is significantly lower than those in the bulk phase and on (100) facet, and the adsorption energy of Mg2+ on the (001) facet is also considerably lower than that on (100) facet, which guarantees superior interfacial Mg2+ storage of (001) facet. Moreover, anatase TiO2 exposed (001) facet displays a significantly higher capacity of 312.9 mAh g−1 in Mg–Li dual-salt electrolyte compared to 234.3 mAh g−1 in Li salt electrolyte. The adsorption energies of Mg2+ on (001) facet are much lower than the adsorption energies of Li+ on (001) facet, implying that the Mg2+ ion interfacial storage is more favorable. These results highlight that controlling the crystal facet of the nanocrystals effectively enhances the interfacial storage of multivalent ions. This work offers valuable guidance for the rational design of high-capacity storage systems.
Diabetes mellitus represents a major global health issue, driving the need for noninvasive alternatives to traditional blood glucose monitoring methods. Recent advancements in wearable technology have introduced skin-interfaced biosensors capable of analyzing sweat and skin biomarkers, providing innovative solutions for diabetes diagnosis and monitoring. This review comprehensively discusses the current developments in noninvasive wearable biosensors, emphasizing simultaneous detection of biochemical biomarkers (such as glucose, cortisol, lactate, branched-chain amino acids, and cytokines) and physiological signals (including heart rate, blood pressure, and sweat rate) for accurate, personalized diabetes management. We explore innovations in multimodal sensor design, materials science, biorecognition elements, and integration techniques, highlighting the importance of advanced data analytics, artificial intelligence-driven predictive algorithms, and closed-loop therapeutic systems. Additionally, the review addresses ongoing challenges in biomarker validation, sensor stability, user compliance, data privacy, and regulatory considerations. A holistic, multimodal approach enabled by these next-generation wearable biosensors holds significant potential for improving patient outcomes and facilitating proactive healthcare interventions in diabetes management.
This review systematically examines the potential of spices and culinary herbs (e.g., turmeric, garlic, ginger) for breast cancer (BC) prevention and treatment, elucidating their underlying mechanisms: inhibiting BC cell proliferation, migration, and metastasis; inducing apoptosis and cell cycle arrest; and modulating dysregulated signaling pathways (e.g., PI3K/Akt/mTOR, NF-κB, Wnt/β-catenin). Notably, their bioactive constituents (e.g., curcumin from turmeric, allicin from garlic, gingerol from ginger) exhibit anti-BC efficacy with fewer adverse effects than conventional chemotherapeutics.
Importantly, it synthesizes in vitro, in vivo, and clinical evidence—for instance, phase I/II trials demonstrating that curcumin combined with docetaxel or paclitaxel improved outcomes in patients with advanced BC. Clinically, these natural agents represent safe, accessible adjuncts to standard BC therapies, though additional large-scale, well-designed clinical trials are required to validate their translational value.