Patients with glioblastoma (GBM)—a type of brain cancer—have a poor prognosis owing to the aggressive nature of GBM disease and limited GBM treatment options. A new study by researchers from Croatia provides critical insights into the transformative role of artificial intelligence (AI) in advancing the diagnosis and treatment of GBM. From accurately distinguishing tumor tissue in GBM to enabling personalized treatment, AI-based tools and models can revolutionize GBM treatment and care.

In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in shaping immune responses within breast cancer microenvironment.

In a paper published in MedComm, embryologists and physicians in the field of reproductive medicine present evidence that DLGAP5 is proposed as a causal gene related to oocyte meiosis disorder for the first time. It expanded the current spectrum of pathogenic genes responsible for the phenotype of oocyte maturation and embryo development defects. It provided a theoretical basis and application values for clinical counseling, genetic diagnosis, and treatment strategies in infertile patients.

Forest fires cause irreversible ecological and economic losses worldwide, often exacerbated by delayed or inefficient rescue efforts. A new study presents a groundbreaking data-driven framework to revolutionize aviation emergency networks. By integrating fire probability predictions with multi-objective optimization, the research enables faster, cost-effective rescue planning tailored to real-world fire risks. Tested in China’s Hainan Province, the model reduces response times while balancing ecological and operational costs—offering a scalable solution for global forest protection.

Contact sports are becoming increasingly popular in Africa, raising concern about the risk of chronic traumatic encephalopathy (CTE). This report highlights the urgent need for awareness, education, and research on CTE across the region. The authors propose a multifaceted approach that includes improving medical infrastructure, increasing funding, addressing sociocultural barriers to brain donation, and educating healthcare professionals. These efforts are essential to prevent serious long-term health consequences and prepare Africa for the growing challenge ahead.

This multicenter study investigates the association between hydroxychloroquine (HCQ) dosage and COVID-19 mortality among hospitalized patients in China, aiming to clarify conflicting evidence from prior research. Leveraging data from multiple medical centers, the analysis focuses on determining whether low-dose HCQ confers mortality benefits with acceptable safety, contrasting with potential risks of higher doses. By systematically evaluating clinical outcomes across different HCQ dosage groups, the research seeks to provide evidence-informed guidance for antiviral therapy in COVID-19 management, particularly in resource-constrained settings.

The study aims to uncover the immunological basis of Tanshi (phlegm-dampness) constitution—a subhealth type in traditional Chinese medicine (TCM)—using single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs). TCM categorizes individuals into nine constitutions, with Tanshi linked to metabolic disorders like diabetes and characterized by symptoms such as heaviness, abdominal flabbiness, and oily skin. By analyzing PBMCs from Tanshi and non-Tanshi individuals, the research seeks to bridge TCM constitutional theory with modern molecular immunology, providing a scientific foundation for TCM’s preventive medicine concept.