Remote regulation of molecular diffusion in extracellular space of Parkinson’s disease rat model by subthalamic nucleus deep brain stimulation
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Jun-2025 14:10 ET (29-Jun-2025 18:10 GMT/UTC)
A research paper by scientists at Peking University Third Hospital presented a study on the regulatory mechanisms of the ECS in the substantia nigra (SN) of PD rats following STN-DBS.A research paper by scientists at Peking University Third Hospital presented a study on the regulatory mechanisms of the ECS in the substantia nigra (SN) of PD rats following STN-DBS.
An innovative strategy to produce bibenzyls from the deoxygenative homocoupling of benzyl alcohols under thea hydrogen atmosphere was developed using iron carbide catalysts. A variety of benzyl alcohols could be efficiently converted into the corresponding bibenzyls over the optimized Ir0.1/Fe0@Fe5C2 catalyst, and a three-component coupling reaction mode was also discovered when alkenes were introduced. Based on control experiments and spectroscopy studies, a reaction mechanism involving C-O bond activation over iron carbide and the formation of benzyl radical species was proposed.
This research shows that 20 μm of the LAF is the most appropriate modification layer thickness.
This study highlights how an online dialogic teaching approach in a university media literacy class fostered students’ global awareness, critical solidarity, and a sense of community when the media provided conflicting narratives of us versus them during the COVID-19 pandemic.
Research team proposed Multi-Projection Recurrent model (MPR) model, effectively tackling polysemy and hierarchy in hypernym detection and discovery with excellent performance.
Background: Percutaneous lung biopsy (PLB) is currently widely utilized in the diagnosis and treatment of lung tumors, owing to its advantages of minimal trauma, high detection rate, and precise localization. However, traditional computed tomography (CT)-guided freehand PLB procedures often involve multiple puncture adjustments and a relatively high incidence of complications. The aim of this study is to investigate whether laser-guided technology can effectively reduce the operative time and incidence of complications.
Methods: This study included 141 patients who underwent CT-guided PLB at the First Affiliated Hospital of Soochow University between January 2022 and January 2024. These patients were divided into two groups based on the use of laser-guided technology during the procedure: the laser-guided group (47 patients) and the manual group (94 patients). Clinical data from all patients were collected. Information such as the success rate of biopsy procedures and the incidence of complications was analyzed and compared.
Results: The procedure time in the laser-guided group was shorter than that in the manual group (P=0.008). In the laser-guided group, the number of adjustments needed to reach the tumor during the positioning step was less than the manual group (P=0.001). In the laser-guided group, the number of CT scans performed before reaching the tumor was smaller than in the manual group (P=0.01). The distance from the first puncture to the lung tumor in the laser-guided group was closer than that in the manual group (P=0.049). The laser-guided group had a smaller angular deviation from the target at the first puncture than the manual group (P=0.004).
Conclusions: Laser-guided technology has the advantages of shorter operation time and less adjustment of biopsy needles. However, laser-guided technology does not reduce the complication rate of biopsy surgery or the length of hospital stay after surgery and there is no statistical difference in the accuracy of pathological diagnoses obtained by the two methods.
Keywords: Laser-guided technology; percutaneous lung biopsy (PLB); lung cancer; pulmonary nodules